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 About 1 result found for searched term "Icotrokinra" (0.128 seconds)

Cat.No.  Name Target
M40707 Icotrokinra IL Receptor/Related
JNJ-2113; JNJ-77242113; PN-235
Icotrokinra (JNJ-77242113, JNJ-2113) is a novel, orally active IL-23R peptide antagonist for studies related to plaque psoriasis. Icotrokinra exhibits high affinity with human IL-23 receptor hIL-23R with a Kd of 7.1 pM. Icotrokinra inhibits IL-23-induced STAT3 phosphorylation in PMBCs (IC50=5.6 pM), and inhibits L-23-induced generation of IFNγ and IL-17A in picomolar levels.



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