About 31 results found for searched term "Enzyme-IN-1" (0.073 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42587 | Enzyme-IN-1 | Proteasome |
| Enzyme-IN-1 is a peptide-based inhibitor of N-terminal nucleophile (Ntn) hydrolases. | ||
| M2418 | AZD1981 | GPR/FFAR |
| AZD1981 is a potent, selective CRTh2 (DP2) receptor antagonist with IC50 of 4 nM, showing >1000-fold selectivity over more than 340 other enzymes and receptors, including DP1. | ||
| M2565 | PR-619 | Deubiquitinase |
| 2,6-Diamino-3,5-dithiocyanopyridine | ||
| PR-619 is a broad-spectrum reversible DUB (deubiquitinating enzyme) inhibitor of USP2, USP4, USP5, USP7 and USP8 with an EC50 of 3-9 μM. PR-619 also induces endoplasmic reticulum stress and endoplasmic reticulum stress-associated apoptosis. | ||
| M2846 | Mevastatin | Others |
| Compactin; ML236B | ||
| Mevastatin is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself. | ||
| M3305 | Tioxolone | Carbonic Anhydrase |
| Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM. | ||
| M3325 | Captopril | Animal Modeling |
| SQ 14225 | ||
| Captopril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM. It can be used to construct animal models of heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM. | ||
| M3400 | Idebenone | Ferroptosis |
| CV-2619 | ||
| Idebenone, a mitochondrial protector, has neuroprotective properties and can be used to study Alzheimer's disease, Huntington's disease, and can cross the blood-brain barrier. Idebenone (oxidized form) inhibited arachidonic acid enzyme metabolism in astrocyte homogenates (IC50=16.65 μM). Idebenone is a coenzyme Q10 analogue and antioxidant that induces apoptosis (apoptotic) in human dopaminergic neuroblastoma SHSY-5Y cells. | ||
| M3426 | Enalaprilat Dihydrate | ACE |
| MK-422 | ||
| Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM. | ||
| M4256 | Gomisin-J | AMPK |
| Gomisin J isa small molecular weight lignan found in Schisandra chinensis with vasodilatory activity. Gomisin J regulates lipogenesis, lipolytic enzyme and inflammatory molecule expression to inhibit lipid accumulation by activating AMPK, LKB1 and Ca2+/ Calmodulin-dependent protein kinase II and inhibiting Fetuin-A in HepG2 cells. Gomisin J has potential benefits in the study of non-alcoholic fatty liver disease. | ||
| M4596 | Silydianin | Phosphatase |
| Silydianin, the active ingredient of silythistle, has anti-collagenase and anti-elastic enzyme activities. Silydianin is a natural protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 value of 17.38 μM. Silydianin inhibited the production and release of oxidation products in vitro. | ||
| M4846 | CC0651 | E1/E2/E3 Enzyme |
| CC 0651, CC-0651 | ||
| CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme and inhibited the ubiquitination of p27Kip1 with IC50 value of 1.72 μM. | ||
| M4945 | Enasidenib | Isocitrate Dehydrogenase (IDH) |
| AG-221 | ||
| Enasidenib is an oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes, with IC50s of 100 and 400 nM against IDH2R140Q and IDH2R172K, respectively. | ||
| M4951 | d-Alaninol | Others |
| Coenzyme B(12)-dependent ethanolamine ammonia-lyase acts on both enantiomers of the substrate 2-amino-1-propanol. | ||
| M6132 | ECBN HCL | Others |
| ECBN obtained by the fermentation of Aspergillus nidulans and Aspergillus rugulosus, is known as one of the natural cyclic hexapeptides that have a linoleoyl side chain, which inhibits a crucial enzyme in fungal cell wall biosynthesis, β-(1,3)-d-glucan synthase. | ||
| M6189 | Ossirene | IL Receptor/Related |
| AS101 | ||
| Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta (IL-1β) converting enzyme. Ossirene abolishes phosphorylation of STAT3 by inhibiting IL-10. Ossirene also inhibits Caspase-1. | ||
| M6216 | TAPI-2 | MMP |
| TAPI-2 is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20±10 μM for MMP. | ||
| M6240 | Angiotensin II human | Animal Modeling |
| Angiotensin II; Hypertensin II; Ang II; DRVYIHPF | ||
| Angiotensin II human is converted by Angiotensin I through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE). Angiotensin II is mediated by AT1 and AT2 receptors, which are seven transmembrane glycoproteins with 30% sequence similarity. Keep away from light and prepare for use now. | ||
| M7315 | Nitrosoglutathione | Others |
| SNOG; GSNO; RVC-588; S-Nitroso-L-glutathione | ||
| Nitrosoglutathione (GSNO; SNOG) is a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses. Breaks down to release NO. | ||
| M7790 | Emodin | Casein Kinase |
| Frangula emodin | ||
| Emodin is an anti-SARS-CoV compound that blocks the interaction between the SARS-coronavirus spike protein and angiotensin converting enzyme 2 (ACE2). Emodin inhibited casein kinase 2 (CK2) and 11β-HSD1. Emodin can also induce necrotic apoptosis of glioma U251 cells and inhibit U251 cell proliferation by targeting the TNF/RIPK1/RIPK3 signaling pathway. | ||
| M8773 | Liarozole dihydrochloride | Others |
| Liarozole (R 75251, R75,251) is an orally active benzimidazole-based retinoic acid (RA) metabolism blocking agent (RAMBA) that targets multiple P450 enzymes, including aromatase (CYP19), 17-hydroxylase/17,20-lyas |
||
| M8783 | Lys05 | Autophagy |
| Lys01 trihydrochloride | ||
| Lys05 (Lys01 trihydrochloride) is a dimeric chloroquine (CQ) that deacidifies the lysosome and causes impairment of lysosomal enzymes, exhibiting more than 10-fold higher autophagy inhibitory potency than hydroxychloroquine (HCQ) and CQ (LC3II/LC3I ratio = 15. | ||
| M9735 | ND-646 | Others |
| ND646 | ||
| ND-646 is an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 with IC50 values of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively. | ||
| M9871 | GSK2643943A | Deubiquitinase |
| GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor targeting USP20/Ub-Rho with an IC50 of 160 nM. GSK2643943A has anti-tumor efficacy and can be used for the research of oral squamous cell carcinoma (OSCC). | ||
| M10070 | LX2343 | BACE |
| LX-2343 | ||
| LX2343 is a BACE1 enzyme inhibitor with IC50 value of 11.43±0.36 μM, and it is a neuroprotective agent. | ||
| M10275 | Bobcat339 | DNA Methyltransferase |
| Bobcat-339 | ||
| Bobcat339 is a novel cytosine-based TET enzyme inhibitor with IC50s of 33 and 73 uM for TET1/2, it does not inhibit the DNA methyltransferase DNMT3a. | ||
| M10582 | Rbin-1 | Phosphatase |
| Ribozinoindole-1 | ||
| Rbin-1 (ribozinoindole-1) is a potent and reversible inhibitor of Midasin (Mdn1), an enzyme belonging to the AAA+ (ATPases associated with diverse cellular activities) protein family (GI50 value 136 nM in wild-type cells). | ||
| M10772 | AB-680 | Immunology/Inflammation |
| AB-680 is a potent, reversible, selective CD73 (extracellular nucleotide enzyme) inhibitor of hCD73 Ki The value is 4.9 pM, which is more than 10,000 times more selective than the associated extracellular nucleotide CD39. Has antitumor activity. | ||
| M10800 | Vanin-1-IN-1 | Others |
| Vanin-1-IN-1 is an inhibitor of the vanin-1 enzyme. Vanin-1 is a cell surface-associated inositol (GPi) anchored protein that plays an important role in metabolism and inflammation. | ||
| M10903 | Cucurbitadienol | Others |
| Cucurbitadienol has significant anti-inflammatory, anti-tumor effect, is also CucurbitacinBE compounds biosynthesis the key intermediate. Cucurbitadienol synthase, the first committed enzyme for cucurbitacin biosynthesis, is a distinct enzyme from cycloartenol synthase for phytosterol biosynthesis. CYP87D18 catalyzed the oxidation of cucurbitadienol at C-11 to produce 11-oxo cucurbitadienol and 11-hydroxy cucurbitadienol. | ||
| M10982 | α-Lipoic Acid | NF-κB |
| Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid | ||
| α-Lipoic Acid is an antioxidant that is an important cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum stress (ER)-mediated apoptosis of liver cancer cells. | ||
| M11175 | WM-3835 | Histone Acetyltransferase |
| WM3835 | ||
| WM-3835 is a potent, highly specific HBO1 (KAT7 or MYST2) inhibitor that binds directly to the acetyl-Coenzyme A binding site of HBO1 33 and WM-3835 activates apoptosis while inhibiting proliferation, migration, and invasion of osteosarcoma (OS) cells. WM-3835 has anti-tumor activity and effectively inhibits the growth of osteosarcoma xenografts in mice. | ||
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