About 1 result found for searched term "Darusentan" (0.131 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M28831 | Darusentan | Endothelin Receptor |
| Lu-135252 | ||
| Darusentan (Lu-135252) is a selective endothelin receptor A (ET-A) receptor antagonist, which binds with a Ki of 1.4 nM to the ET-A receptor and a Ki of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors. Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a Ki of 13 nM. | ||
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