About 7 results found for searched term "DUB-IN-1" (0.129 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M13625 | DUB-IN-1 | Deubiquitinase |
| DUB-IN-1 is an active inhibitor of ubiquitin-specific proteases (USPs), with an IC50 of 0.85 μM for USP8. | ||
| M2565 | PR-619 | Deubiquitinase |
| 2,6-Diamino-3,5-dithiocyanopyridine | ||
| PR-619 is a broad-spectrum reversible DUB (deubiquitinating enzyme) inhibitor of USP2, USP4, USP5, USP7 and USP8 with an EC50 of 3-9 μM. PR-619 also induces endoplasmic reticulum stress and endoplasmic reticulum stress-associated apoptosis. | ||
| M3052 | TCID | Deubiquitinase |
| TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1. | ||
| M9871 | GSK2643943A | Deubiquitinase |
| GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor targeting USP20/Ub-Rho with an IC50 of 160 nM. | ||
| M25343 | Sudubrilimab | PD-1/PD-L1 |
| HS636 | ||
| Sudubrilimab (HS636) is an Ig G1-kappa monoclonal antibody against PDL1. Sudubrilimab is fused at the C terminus of the heavy chain to a TGF-β1 receptor Ⅱ ectodomain (TGFBR2-ECD), and which can sequester the PD-1/PD-L1 pathway and TGF-β bioactivity in the immunosuppressive tumor microenvironment. | ||
| M54656 | NJH-2-056 | Others |
| NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) linking EN523, a recruitment factor for OTUB1, to lumacaftor, a CFTR chaperone protein.NJH-2-056 can be used in cystic fibrosis-related studies. | ||
| M54866 | Recombinant Human USP14 (E.coli, N-6His) | Recombinant Proteins |
| Ubiquitin Carboxyl-Terminal Hydrolase 14; Deubiquitinating Enzyme 14 | ||
| USP14 belongs to the ubiquitin-specific processing (USP) family which is a deubiquitinating enzyme (DUB) with His and Cys domains. USP14 acts also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. | ||
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