About 34 results found for searched term "DNA polymerase" (0.253 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41459 | DNA polymerase-IN-2 | DNA/RNA Synthesis |
| DNA polymerase-IN-2, a coumarin derivative, exhibits inhibitory activity against Taq DNA polymerase with IC50 of 48.25 μM , which can be used in value-added disease research. | ||
| M41460 | DNA polymerase-IN-3 | DNA/RNA Synthesis |
| DNA polymerase-IN-3 is a coumarin derivative that exhibits inhibitory activity against Taq DNA polymerase and can be used in proliferative disease research. | ||
| M42935 | DNA polymerase-IN-4 | Others |
| DNA polymerase-IN-4, a coumarin derivative, has antiretroviral activity with IC50 value of 134.22 μM. | ||
| M50288 | DNA polymerase | Enzymes & Coenzymes |
| DNA polymerase is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||
| M1698 | Clofarabine | DNA/RNA Synthesis |
| Clolar, Evoltra | ||
| Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase. | ||
| M2028 | Fludarabine | STAT |
| Fludara; NSC 118218; Fludarabinum; F-ara-A | ||
| Fludarabine (NSC 118218) is a STAT1 activation inhibitor and a DNA synthesis inhibitor. Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. Fludarabine markedly inhibited VSMC proliferation in cell culture. Fludarabine also induces significant reduction of STAT-1 phosphorylation, whereas it does not change JAK2 activation. Fludarabine exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. | ||
| M2713 | Foscarnet Sodium | Others |
| Phosphonoformate | ||
| Foscarnet Sodium inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive inhibition with dNTPs. | ||
| M3892 | BMH-21 | DNA/RNA Synthesis |
| BMH-21 is a first-in-class DNA intercalator that binds to high-frequency GC-rich sequences in ribosomal DNA genes and can effectively and rapidly inhibit the transcription of RNA polymerase I (Pol I), leading to degradation of the Pol I catalytic subunit RPA194 and non-phosphorylation of histone H2AX. H2AX is not phosphorylated.BMH-21 has broad and potent antitumor activity in NCI60 cancer cell line and inhibits tumor growth in vivo. | ||
| M5061 | Valacyclovir hydrochloride | Anti-infection |
| Valaciclovir hydrochloride | ||
| Valaciclovir HCl, an aciclovir procompound, inhibits activity of virus DNA polymerase, used to treat infections caused by herpes simplex virus (HSV) and varicella zoster virus, and for prophylaxis against cytomegalovirus (CMV). | ||
| M5526 | Clevudine | DNA/RNA Synthesis |
| Clevudine (L-FMAU) is a nucleoside analogue with unnatural L-configuration, which has strong anti-HBV activity, long half-life and low toxicity. Clevudine is a non-competitive inhibitor that binds not to viral DNA but to the polymerase. | ||
| M5767 | Menadione (Vitamin K3) | DNA/RNA Synthesis |
| Menadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement. | ||
| M5930 | Rifampicin | DNA/RNA Synthesis |
| NSC-113926; Rimactane; Rifamycin; Rifadin; Rifater | ||
| Rifampin is a DNA-dependent RNA polymerase inhibitor, it is also a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities. | ||
| M6056 | Vitamin D2 | DNA Methyltransferase |
| Ergocalciferol | ||
| Vitamin D2 is a selective inhibitor of mammalian DNA polymerase A (pol A) with IC50 of 123 mM. | ||
| M7506 | 5-methoxyflavone | DNA/RNA Synthesis |
| 5-MF | ||
| 5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. | ||
| M6443 | AM-TS23 | Others |
| AM-TS23 is a dNA polymerase λ and β inhibitor. | ||
| M6449 | Aphidicolin | DNA/RNA Synthesis |
| Aphidicolin is a DNA polymerase α, δ and ε inhibitor. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. | ||
| M7515 | Brivudine | DNA/RNA Synthesis |
| BVDU | ||
| Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication. | ||
| M7963 | Nalidixic acid sodium salt | Antibiotic |
| Nalidixic acid sodium salt is an inhibitor of bacterial DNA polymerase (DNA gyrase) and avian myeloblastoma virus reverse transcriptase. Nalidixic acid sodium salt is a quinolone antibiotic, it is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. | ||
| M8134 | RU7 | Others |
| RU7 is a selective inhibitor of bacterial β-clamp interaction with DNA polymerase POL III, and an inhibitor of a DNA polymerase sliding clamp. | ||
| M8265 | Adefovir | Anti-infection |
| GS-0393; PMEA | ||
| Adefovir is an antiviral compound that inhibits hepatitis B virus (HBV) DNA polymerase (reverse transcriptase) after intracellular conversion to adefovir diphosphate. | ||
| M8400 | Fialuridine | DNA/RNA Synthesis |
| FIAU; DRG-0098 | ||
| Fluuridine is a nucleoside antiviral compound. The compound showed significant mitochondrial toxicity. Fialuridine is also a DNA-directed DNA polymerase inhibitor that may be used to treat HBV infection and has potent activity against hepatitis B virus in vivo and in vitro. FIAU blocks DNA synthesis of human cytomegalovirus, hepatitis B and herpes simplex viruses. | ||
| M9589 | Rifamycin sodium | Antibiotic |
| Rifamycin sodium salt | ||
| Rifamycin sodium belongs to the family of ansamycin antibiotics, it is an antibiotic that inhibits bacterial DNA-dependent RNA polymerase. | ||
| M11532 | T7 RNA Polymerase (E. coli) | Nucleic Acid Extraction and Purification |
| T7 RNA polymerase is a DNA-dependent RNA polymerase that specifically recognizes the T7 promoter sequence (5' -TaatacgactCactatagggaga-3 ') and has high specificity for the phage T7 promoter sequence. T7 RNA polymerase can catalyze NTP incorporation of single or double stranded DNA template downstream of T7 promoter to synthesize RNA complementary to the downstream DNA template of T7 promoter. | ||
| M13448 | Letermovir (AIC246) | Anti-infection |
| MK-8228 | ||
| Letermovir (AIC246) is a novel and potent anti-CMV compound that targets viral terminal enzyme complexes and is active in viruses that are resistant to DNA polymerase inhibitors. | ||
| M13643 | Cytarabine hydrochloride | DNA/RNA Synthesis |
| Cytosine β-D-arabinofuranoside hydrochloride; Cytosine Arabinoside hydrochloride; Ara-C hydrochloride | ||
| Cytarabine hydrochloride, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine hydrochloride has antiviral effects against HSV. | ||
| M20794 | Menadione bisulfite sodium | Phosphatase |
| Menadione sodium bisulfite, Vitamin K3 sodium bisulfite | ||
| Menadione(Vitamin K3) bisulfite sodium, a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement. | ||
| M21168 | ART558 | DNA/RNA Synthesis |
| ART-558 | ||
| ART558 is a nanomolar, highly potent, selective, low-molecular-weight, variant DNA polymerase active Polθ inhibitor (IC50=7.9 nM). ART558 can be used in cancer research. | ||
| M21508 | Ibezapolstat | Antibiotic |
| ACX-362E; GLS-362E | ||
| Ibezapolstat (ACX-362E) is a first-of-its-kind (first-in-class) inhibitor of the orally active DNA polymerase IIIC (DNA pol IIIC) developed for use in the study of Clostridium difficile infection (CDI). | ||
| M21557 | RP-6685 | DNA/RNA Synthesis |
| RP-6685 is a potent, selective and orally active inhibitor of DNA polymerase θ (Polθ) with an IC50 value of 5.8 nM (PicoGreen assay). RP-6685 showed antitumor effect in mouse tumor transplantation model. | ||
| M21558 | ART812 | DNA/RNA Synthesis |
| ART812 is an orally effective DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. ART812 had an IC50 value of 240 nM for cell-based microhomologous mediated end-junction (MMEJ). | ||
| M28131 | Rifalazil | DNA/RNA Synthesis |
| KRM-1648; ABI-1648 | ||
| Rifalazil (KRM-1648; ABI-1648), a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase. Rifalazil (KRM-1648; ABI-1648) is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis with MIC values from 0.00025 to 0.0025 μg/ml. | ||
| M28265 | Delavirdine | HIV Protease |
| U 90152; BHAP-U 90152 | ||
| Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC50=0.26 μM) over DNA polymerase α (IC50=440 μM) and polymerase δ (IC50>550 μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs. | ||
| M28542 | Emivirine | HIV Protease |
| MKC-442 | ||
| Emivirine (MKC-442) is a non-nucleoside reverse transcriptase inhibitors (NNRTIs) with Ki values of 0.20 and 0.01 μM for dTTP- and dGTP-dependent DNA or RNA polymerase activity, respectively. Emivirine displays potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity. | ||
| M28944 | FF-10502 | Nucleoside Antimetabolite/Analog |
| FF-10502, a structural analog of Gemcitabine, is a pyrimidine nucleoside antimetabolite. FF-10502 inhibits DNA polymerase α and β. FF-10502 shows beneficial anticancer activity via a mechanism of action on dormant cells. | ||
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