About 12 results found for searched term "Colchicine" (0.126 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3460 | Colchicine | Microtubule |
| Colchicine is a natural product extracted from Colchicum spp. It is also a tubulin inhibitor and microtubule disruptor with an IC50 of 3 nM for inhibition of microtubule polymerization, and a competitive antagonist of α3 glycine receptors (GlyRs). Colchicine is also a competitive antagonist of α3 Glycine receptors (GlyRs) and has been used in gout research. | ||
| M18870 | Thiocolchicine | Others |
| Thiocolchicine | ||
| M44951 | N-Methylcolchicine | Others |
| Micromarin F is synthesized from osthole. Micromarin F against Balanus albicostatus and Bugula neritina with EC50 values of 10.93 and 12.38 μM. | ||
| M56394 | 3-Demethylcolchicine | ROS |
| 3-Demethylcolchicine, a colchicine metabolite, possesses a hydroxy-group on its carbon ring that could participate in radical scavenging and markedly inhibits the carrageenin edema. | ||
| M3755 | D-64131 | Microtubule |
| D-64131 is a novel inhibitor of Tubulin polymerization that competitively binds with [(3)H]colchicine to αβ-Tubulin and inhibits tumor cell proliferation in vitro (IC50 = 74 nM). | ||
| M3901 | Combretastatin A4 | Microtubule |
| CRC 87-09, NSC 817373, CA-4 | ||
| Combretastatin A4 (CA-4), which is a natural stilbene isolated from Combretum caffrum, is a microtubule-destabilizing agent that binds to the colchicine domain on β-tubulin and exhibits a lower toxicity profile than paclitaxel or the Vinca alkaloids. | ||
| M8835 | UA62784 | Others |
| Studies have also reported that UA62784 associates with tubulin at or near the colchicine-binding sites in cells and functions as a cytotoxic, microtubule inhibitor. | ||
| M29668 | YS-370 | P-glycoprotein |
| YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein (P-gp). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity. | ||
| M30624 | Avanbulin | Microtubule |
| BAL27862 | ||
| Avanbulin (BAL27862) is a potent, Colchicine site-binding, tubulin assembly inhibitor. Avanbulin inhibits tubulin assembly at 37 °C with an IC50 of 1.4 μM. Avanbulin binds to tubulin with an apparent Kd value of 244 nM. Avanbulin can be used for the research of cancer and cell division. | ||
| M41531 | MY-673 | Microtubule |
| MY-673 is a colchicine binding site inhibitor (CBSI), that inhibits tubulin polymerization. | ||
| M42109 | 8-Epixanthatin | STAT |
| 8-Epixanthatin is a potential colchicine binding site inhibitor isolated from Xanthium chinese Mill. | ||
| M45015 | Tartaric acid disodium dihydrate | Phosphatase |
| Tartaric acid disodium dihydrate is a Acid phosphatase inhibitor, is a sodium salt used in buffers for molecular biology and cell culture applications. Tartaric acid disodium dihydrate increases the rate of colchicine binding to tubulin1. | ||
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