About 1 result found for searched term "Cinrebafusp alfa" (0.122 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M24993 | Cinrebafusp alfa | EGFR/HER2 |
| PRS 343 | ||
| Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (Kd=0.3 nM) and human monomeric CD137 (4-1BB; Kd=5 nM). Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research. | ||
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