About 32 results found for searched term "Cathepsin D" (0.111 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M50356 | Cathepsin D | Enzymes & Coenzymes |
| Cathepsin D (CTSD) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||
| M52668 | Cathepsin D and E FRET Substrate | Cathepsin |
| Cathepsin D and E FRET Substrate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. | ||
| M1985 | Odanacatib | Cathepsin |
| MK-0822 | ||
| Odanacatib (MK-0822) is a potent and reversible covalent inhibitor of CathepsinK (CatK) with an IC50 of 0.2 nM/1 nM for human/rabbit cathepsin B, L, and S and is highly selective. | ||
| M1987 | LY2886721 | BACE |
| LY2886721 is an effective, selective, orally active inhibitor of beta-site amyloid precursor protein lyase 1 (BACE1) with an IC50 of 20.3 nM against recombinant human BACE1. LY2886721 showed higher selectivity for BACE1 than cathepsin D, pepsin and renin, but lacked selectivity for BACE2 (IC50 was 10.2 nM). LY2886721 crosses the blood-brain barrier and can be used to study Alzheimer's disease. | ||
| M2600 | Balicatib | Cathepsin |
| AAE-581 | ||
| Balicatib is a potent and selective inhibitor of cathepsin K; 10-100-fold more potent in cell-based enzyme occupancy assays than against cathepsin B, L, and S. | ||
| M2497 | Cathepsin Inhibitor 1 | Cathepsin |
| Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. | ||
| M3636 | Leupeptin hemisulfate | Cathepsin |
| Leupeptin hemisulfate hemisulfate is the reversible inhibitor of lysosomal serine and cysteine proteinases; Leupeptin; inhibition of cathepsin B(Ki=6 nM), calpain(Ki=10 nM), trypsin (Ki=35 nM), plasmin (Ki=3.4 μM) and kallikrein (Ki=19 μM) had no effect on chymotrypsin, elastase, renin, or pepsin. | ||
| M4767 | aurantiamide-acetate | Cathepsin |
| Aurantiamide acetate is a selective and orally active cathepsin inhibitor isolated from Portulaca Oleracea L. Aurantiamide acetate has anti-inflammatory activity and can be used to study inflammatory diseases. | ||
| M5221 | MG-101 | Proteasome |
| Calpain inhibitor I; Ac-LLnL-CHO; ALLN | ||
| MG-101 is a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). IC50 value: 150 nM (Ki) | ||
| M10280 | L006235 | Cathepsin |
| L235; L-006235; L-235 | ||
| L006235 (L235) is a potent, reversible cathepsin K inhibitor (IC50 = 0.25 nM) that displays > 4000-fold selectivity over cathepsins B, L and S. | ||
| M10412 | Val-cit-PAB-OH | ADC Linker |
| Val-cit-PAB-OH is a cathepsin cleavable ADC peptide linker for making MC-Val-Cit-PAB, which is also known as MC-Val-Cit-PAB-OH. | ||
| M10900 | AZD3839 free base | BACE |
| AZD3839 free base is a potent and selective orally active, brain-permeable BACE1 inhibitor (Ki=26 nM). AZD3839 free base shows 14 and >1000-fold selectivity against BACE2 and cathepsin D, respectively. | ||
| M11252 | Recombinant Human Cathepsin B (CHO，His) | Cytokines and Growth Factors |
| Cathepsin B; APP secretase; APPS | ||
| Cathepsin B is an enzymatic protein that is a member of the peptidase (or protease) family. | ||
| M13538 | Z-WEHD-FMK | Caspase |
| Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis. | ||
| M14307 | LY 3000328 | Cathepsin |
| LY 3000328 is a potent and selective Cathepsin S (Cat S) inhibitor with IC50s of 7.7 and 1.67 nM for hCat S and mCat S, respectively. | ||
| M20820 | Gly-Phe β-naphthylamide | Others |
| Gly-Phe beta-naphthylamide | ||
| Gly-Phe β-naphthylamide (Gly-Phe beta-naphthylamide) is a substrate of cathepsin C that accumulates within the lysosome. Gly-Phe-β-naphthylamide can inhibit the cathepsin-dependent activation of caspase-8. | ||
| M21400 | LHVS | Cathepsin |
| LHVS is a potent, non-selective, irreversible, cell-permeable inhibitor of cysteine protease and cathepsin. lHVS reduces actin ring formation. lHVS inhibits T. gondii invasion with an IC50 of 10 μM. | ||
| M27794 | ALLM | Proteasome |
| Calpain inhibitor II | ||
| ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI). | ||
| M27825 | KGP94 | Cathepsin |
| KGP94 is a selective inhibitor of cathepsin L with an IC50 of 189 nM. KGP94 inhibits migration and invasion of metastatic carcinoma and shows low cytotoxicity (GI50=26.9 µM) against various human cell lines. | ||
| M28042 | Petesicatib | Cathepsin |
| Petesicatib is a cathepsin S inhibitor, used in research of immune diseases. | ||
| M28091 | NB-360 | Gamma-secretase/Beta-secretase |
| NB-360 is a potent, brain penetrable, and orally bioavailable dual BACE1/BACE2 inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM). NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice. NB-360 shows excellent selectivity over the related aspartyl proteases pepsin, cathepsin D and cathepsin E. | ||
| M28225 | MIV-247 | Cathepsin |
| MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively. | ||
| M28683 | GSK2793660 hydrochloride | Cathepsin |
| GSK2793660 hydrochloride is an orally active, irreversible cathepsin C (CTSC) inhibitor for bronchodilation studies. | ||
| M29515 | K777 | Cathepsin |
| K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and EBOV pseudovirus entry with IC50 values of 0.68 nM and 0.87 nM, respectively. | ||
| M29733 | JPM-OEt | Cathepsin |
| JPM-OEt is a broad spectrum cysteine cathepsin inhibitor. JPM-OEt binds covalently in the active site, and irreversibly inhibits the cysteine cathepsin family. Antitumor activity. | ||
| M29991 | Relacatib | Cathepsin |
| SB-462795 | ||
| Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Relacatib inhibits endogenous cathepsin K in situ in human osteoclasts and human osteoclast-mediated bone resorption with IC50 values of 45 nM and 70 nM, respectively. Relacatib inhibits bone resorption in vitro in human tissue as well as in cynomolgus monkeys in vivo. | ||
| M30349 | L-873724 | Cathepsin |
| L-873724 is a potent, orally bioavailable, selective and reversible[2] non-basic cathepsin K inhibitor, with IC50s of 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively. L-873724 also exhibits an IC50 of 0.5 nM for rabbit cathepsin K. L-873724 inhibits bone resorption. | ||
| M30755 | ONO-5334 | Cathepsin |
| ONO-5334 is a potent, selective and orally active cathepsin K inhibitor with Ki values of 0.10 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively. ONO 5334 is an effective antiviral compound against SAR-COV-2 virus activity with an EC50 value of 500 nM. ONO-5334 has the potential for the study of osteoporosis and COVID-19 disease. | ||
| M41002 | AcLys-PABC-VC-Aur0101 intermediate-1 | ADC Linker |
| AcLys-PABC-VC-Aur0101 intermediate-1 is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. | ||
| M42302 | Cathepsin C-IN-6 | Cathepsin |
| Cathepsin C-IN-6 is a E-64c-hydrazideas based inhibitor of cathepsin C with anti-inflammatory activity. | ||
| M42905 | Cathepsin Inhibitor 3 | Others |
| Cathepsin Inhibitor 3 is a non-radioactive intermediate in compound [18F] 2k radioactive synthesis, which has selectivity for cathepsin S. | ||
| M42922 | Z-Nle-Lys-Arg-AMC | Others |
| Z-Nle-Lys-Arg-AMC is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range. | ||
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