About 10 results found for searched term "Caf1-IN-1" (0.135 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M43422 | DCAF1 binder 1 | Ligand for E3 Ligase |
| DCAF1 binder 1 is a selective for the CRL4 DCAF1 E3 ligase complex. | ||
| M58164 | Caf1-IN-1 | DNA/RNA Synthesis |
| Compound 8j | ||
| Caf1-IN-1 is inhibitor for ribonuclease Caf1 with an IC50 of 0.59 µM. Caf1-IN-1 is also a weak inhibitor for poly(A)-specific ribonuclease (PARN) with IC50 of 23.9 µM. | ||
| M4752 | L-Chicoric Acid | HIV Protease |
| (-)-Chicoric acid; trans-Caffeoyltartaric acid | ||
| L-chicoric Acid ((-)-Chicoric Acid), a dicafoyl tartaric Acid, is a potent, selective and reversible INHIBITOR of HIV-1 integrase with an IC50 of approximately 100 nM. L-chicoric Acid also inhibits HIV-1 replication in tissue cultures. | ||
| M20775 | SEC inhibitor KL-1 | Others |
| KL-1 | ||
| SEC inhibitor KL-1 (KL-1) is a potent and selective inhibitor of super elongation complex (SEC) that disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with Ki of 3.48 μM. | ||
| M29586 | KB02-JQ1 | PROTAC |
| KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3. KB02-JQ1 promotes BRD4 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. JQ1 binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-JQ1. | ||
| M30840 | SEC inhibitor KL-2 | Others |
| KL-2 | ||
| SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM. | ||
| M43153 | CYCA-117-70 | Ligand for E3 Ligase |
| CYCA-117-70 is a DCAF1 ligand (KD: 70 μM). CYCA-117-70 is an ideal chemical handles for PROTACs recruiting DCAF1. | ||
| M43420 | OICR-8268 | Ligand for E3 Ligase |
| OICR-8268 is a reversible DCAF1 ligand that binds to the DCAF1 WDR domain with a Kd of 38 nM. | ||
| M58123 | OICR-8268 | Ligand for E3 Ligase |
| OICR8268 | ||
| OICR-8268 is a reversible DCAF1 ligand that binds to the DCAF1 WDR domain with a Kd of 38 nM. OICR-8268 can be used in the development of DCAF1-based PROTACs. | ||
| M54770 | 1-Methylxanthine | Metabolite/Endogenous Metabolite |
| 1-MTX | ||
| 1-Methylxanthine, a caffeine derivative, is an essential human urinary metabolite of caffeine and theophylline (1,3-dimethylxanthine, TP). 1-Methylxanthine enhances the radiosensitivity of tumor cells. | ||
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