About 4 results found for searched term "CU-115" (0.187 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M10810 | CU-115 | TLR |
| CU115 | ||
| CU-115 is a potent TLR8 antagonist (IC50=1.04 µM), and shows selective for TLR8 over TLR7 (IC50=>50 µM). CU-115 decreases TNF-α and IL-1β production activated by R-848 in THP-1 cells. | ||
| M2182 | RG108 | DNA Methyltransferase |
| N-Phthalyl-L-tryptophan | ||
| RG108 is a novel small-molecule inhibitors of DNA methyltransferases with IC50 of 115 nM. | ||
| M21755 | Barasertib | Aurora Kinase |
| AZD1152 | ||
| Barasertib (AZD1152), a precursor of Barasertib-hQPA, is a highly selective Aurora B inhibitor with an IC50 of 0.37 nM in a cell-free assay. Barasertib (AZD1152) induces growth arrest and apoptosis in cancer cells. | ||
| M58191 | Calphostin C | Wnt/beta-catenin |
| PKF115-584; UCN-1028C | ||
| Calphostin C (PKF115-584) is a small molecule inhibitor of Wnt/beta-catenin/lef-1 signaling. Calphostin C is also a potent and specific inhibitor of protein kinase C. PKF115-584 efficiently killed CLL cells (LC(50)<1 microM), whereas normal B cells were not significantly affected. | ||
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