About 2 results found for searched term "CI-1044" (0.133 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M22042 | CI-1044 | Others |
| CI-1044 | ||
| M25179 | KY-1044 | Others |
| Alomfilimab; SAR 445256 | ||
| KY-1044 (Alomfilimab; SAR 445256) is a fully human IgG1 antibody targeting inducible costimulatory receptor (ICOS). KY-1044 depletes ICOShigh cells via antibody-dependent cellular cytotoxicity (ADCC) through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels, such as CD8+ TEff cells (through FcgR-dependent clustering). KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response. | ||
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