About 7 results found for searched term "CHK1-IN-7" (0.133 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41445 | CHK1-IN-7 | Checkpoint |
| CHK1-IN-7 is a potent human CHK1 inhibitor. | ||
| M1764 | PF-477736 | Checkpoint |
| PF-0044736 | ||
| PF-477736 is a selective checkpoint kinase 1 (Chk1) inhibitor with Ki values of 0.49 nM and 47 nM for CHK1 and CHK2 respectively. | ||
| M2324 | Rabusertib (LY2603618) | Checkpoint |
| Rabusertib ; IC-83 | ||
| Rabusertib (LY2603618) is an effective and selective Chk1 inhibitor with an IC50 of 7 nM. | ||
| M9208 | PD0166285 | Checkpoint |
| PD166285 | ||
| PD0166285 is a potent Wee1 inhibitor and Chk1 inhibitor with IC50s of 24 nM and 72 nM, respectively. | ||
| M13620 | CCT244747 | Checkpoint |
| CCT244747 is a potent, orally bioavailable and highly selective CHK1 inhibitor, with an IC50 of 7.7 nM; CCT244747 also abrogates G2 checkpoint with an IC50 of 29 nM. | ||
| M27916 | GDC0575 hydrochloride | Checkpoint |
| ARRY-575 hydrochloride; RG7741 hydrochloride | ||
| GDC0575 (ARRY-575) hydrochloride is a highly-selective and orally active Chk1 (IC50=1.2 nM) inhibitor. GDC0575 (ARRY-575) hydrochloride can be used for colitis-associated cancer (CAC) and colitis research. | ||
| M45307 | Multi-kinase-IN-6 | Casein Kinase |
| Multi-kinase-IN-6 is a multikinase inhibitor that shows good enzyme inhibitory activity against TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1 and CDK2. In addition, Multi-kinase-IN-6 also showed antiproliferative activity against MCF7, HCT116 and EKVX, with IC50 values of 3.36 μM, 1.40 μM and 3.49 μM, respectively, and showed good apoptotic activity in MCF7 and HCT116 cells with cell-cycle arrest in G1/S and G1 phases. phase, with good apoptosis effect. | ||
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