About 2 results found for searched term "Branaplam" (0.125 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M13649 | Branaplam | DNA/RNA Synthesis |
| LMI070; NVS-SM1 | ||
| Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. | ||
| M50222 | Branaplam hydrochloride | DNA/RNA Synthesis |
| LMI070 hydrochloride; NVS-SM1 hydrochloride | ||
| Branaplam hydrochloride is an orally active, brain-permeable, selective modulator of SMN2 splicing, with an EC50 of 20 nM for SMN, and enhances full-length SMN protein and prolongs survival in a mouse model of severe spinal muscular atrophy (SMA). Branaplam hydrochloride also inhibits hERG with an IC50 of 6.3 μM. | ||
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