About 1 result found for searched term "BPN-15606 besylate " (0.137 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M31065 | BPN-15606 besylate | Gamma-secretase/Beta-secretase |
| BPN-15606 besylate is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 besylate lowers Aβ42 and Aβ40 levels in the central nervous system of rats and mice. BPN-15606 besylate has acceptable PK/PD properties, including bioavailability, half-life, and clearance. | ||
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