About 8 results found for searched term "BET-IN-15" (0.12 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41646 | BET-IN-15 | Epigenetic Reader Domain |
| BET-IN-15 is a potent and orally active BET inhibitor with IC50 values of 0.64, 0.25 nM for BRD4-BD1, BRD4-BD2, respectively. | ||
| M14860 | PI4KIIIbeta-IN-9 | PI3K |
| PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively. | ||
| M19993 | Recombinant Human B4GALT1 (HEK293, C-6His) | Cytokines and Growth Factors |
| 1,4- galactosyltransferase, polypeptide 1; B4GalT1 | ||
| Beta1,4-Galactosyltransferase-I (B4GALT1) is an enzyme commonly found in the trans-Golgi complex that adds galactose to oligosaccharides. Accession: P15291. | ||
| M28690 | SDZ 224-015 | IL Receptor/Related |
| SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and caspase-1. SDZ 224-015 possesses anti-COVID-19 activity, targeting Mpro (IC50 of 30 nM). | ||
| M28768 | BDM-2 | HIV Protease |
| BDM-2 is an IN-LEDGF allosteric inhibitor (INLAI) of HIV-1 integrase (IN refers to integrase) (IC50=47 nM) with potent anti-Retroviral (ARV) activity. BDM-2 shows IN multimerization activation effect with an AC50 value of 20 nM. BDM-2 blocks the interaction between the catalytic core domain of IN (IN-CCD) and the Integrase binding domain of LEDGF/p75 (IBD), with an IC50 value of 0.15 μM. BDM-2 exhibits highly selective and favorable cytotoxicity. | ||
| M31282 | Mag-Fluo-4 AM | Fluorescent Dye |
| Mag-Fluo-4 AM is a fluorescent chelator for Ca2+ with high affinity for calcium and can specifically recognize intracellular calcium ions with high sensitivity and low cytotoxicity. Addition of AM acetylmethyl ester allows better access to the cell, and after being sheared by the intracellular esterase, it stays in the cell and binds to calcium ions, thus generating strong fluorescence (λex=475 nm, λem=515 nm). | ||
| M58183 | Recombinant Mouse IL-15 (E. coli, N-His) | Cytokines and Growth Factors |
| interleukin 15 | ||
| Interleukin-15 (IL-15) is a 14-15 kDa glycoprotein with immune regulatory functions in many diverse cell types. As a pleiotropic cytokine, IL-15 mediates the crosstalk between innate immunity and adaptive immunity whose principal role is to kill virally infected cells. IL-15 plays a crucial role in the development, differentiation, and survival of NK cells. | ||
| M58191 | Calphostin C | Wnt/beta-catenin |
| PKF115-584; UCN-1028C | ||
| Calphostin C (PKF115-584) is a small molecule inhibitor of Wnt/beta-catenin/lef-1 signaling. Calphostin C is also a potent and specific inhibitor of protein kinase C. PKF115-584 efficiently killed CLL cells (LC(50)<1 microM), whereas normal B cells were not significantly affected. | ||
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