About 4 results found for searched term "BACE1-IN-10" (0.235 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M52425 | BACE1-IN-10 | Gamma-secretase/Beta-secretase |
| BACE1-IN-10 is a potent BACE1 Inhibitor. | ||
| M1987 | LY2886721 | BACE |
| LY2886721 is an effective, selective, orally active inhibitor of beta-site amyloid precursor protein lyase 1 (BACE1) with an IC50 of 20.3 nM against recombinant human BACE1. LY2886721 showed higher selectivity for BACE1 than cathepsin D, pepsin and renin, but lacked selectivity for BACE2 (IC50 was 10.2 nM). LY2886721 crosses the blood-brain barrier and can be used to study Alzheimer's disease. | ||
| M10900 | AZD3839 free base | BACE |
| AZD3839 free base is a potent and selective orally active, brain-permeable BACE1 inhibitor (Ki=26 nM). AZD3839 free base shows 14 and >1000-fold selectivity against BACE2 and cathepsin D, respectively. | ||
| M28304 | Umibecestat | Gamma-secretase/Beta-secretase |
| CNP520 | ||
| Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of alzheimer's disease. | ||
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