About 9 results found for searched term "AZ82" (0.07 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2295 | AZD6482 | PI3K |
| KIN 193 | ||
| AZD6482 is an inhibitor of PI3Kβ with IC50 of 21 nM. AZD6482 is particularly effective in blocking AKT signaling and tumor growth dependent on p110β activation or PTEN loss. | ||
| M10702 | AZD5582 | IAP |
| AZD5582 is an IAP antagonist that can be effectively combined with bir3 domains of cIAP1, cIAP2, and XIAP, IC50 The values are 15, 21, 15 nM, respectively. AZD5582 Induces apoptosis. | ||
| M13687 | AZ82 | Kinesin |
| AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1. | ||
| M14857 | (Rac)-AZD 6482 | PI3K |
| (Rac)-KIN-193 | ||
| (Rac)-AZD 6482 ((Rac)-KIN-193) is the racemate of AZD 6482. AZD 6482 is a potent and selective p110β inhibitor with an IC50 of 0.69 nM. | ||
| M21069 | AZ13824374 | Epigenetic Reader Domain |
| AZ13824374 is an in vitro ATAD2 inhibitor with anti-proliferative activity against breast cancer. pIC50 of AZ13824374 against ATAD2 in the ATAD2 FRET and ATAD2 NanoBRET assays were 8.2 and 6.2, respectively. | ||
| M28932 | AZ9482 | PARP |
| AZ9482 is a triple PARP1/2/6 inhibitor, with IC50 values of 1 nM, 1 nM and 640 nM for PARP1, PARP2 and PARP6, respectively. | ||
| M45105 | Naproxcinod | COX |
| AZD 3582; HCT 3012; Nitronaproxen | ||
| Naproxcinod is a first-of-its-kind (first-in-class) cyclooxygenase-inhibiting nitric oxide donors (CINODs) with analgesic and anti-inflammatory activity for studies related to osteoarthritis and inflammation. | ||
| M45125 | AZD-8233 | PCSK9 |
| AZD-8233 is an orally active, antisense oligonucleotide (ASO) targeting PCSK9 that targets and inhibits the translation and protein synthesis of PCSK9 mRNA in hepatocytes and reduces circulating LDL-C levels. It can be used in studies related to hypercholesterolemia. | ||
| M55895 | AZD5582 dihydrochloride | IAP |
| AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. | ||
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