About 20 results found for searched term "APE1-IN-1" (0.148 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M54851 | APE1-IN-1 | DNA/RNA Synthesis |
| APE1-IN-1 is a potent and blood-brain barrier (BBB) penetrant apurinic/apyrimidinic (AP) endonuclease 1 (APE1) inhibitor with an IC50 value of 2 μM. APE1-IN-1 can potentiate the cytotoxicity of the alkylating agents Methylmethane sulfonate to cancer cells. | ||
| M6972 | ML221 | Apelin Receptor |
| ML-221 | ||
| ML221 is an Apelin (APJ) antagonist and inhibits apelin-13-mediated activation of APJ. IC50 values of cAMP and β -Arrestin were 0.70 μM and 1.75 μM, respectively. EC80 values were all 10 nM. | ||
| M13365 | Nonapeptide-1 acetate salt | Melanocortin Receptor |
| Melanostatine-5 acetate salt | ||
| Nonapeptide-1 acetate salt is apeptide hormone, which is a potent antagonist of α -melanocyte-stimulating hormone (α-MSH) with an IC50 value of 11 nM. Nonapeptide-1 (Melanostatine-5) acetate salt is a selective antagonist of MC1R (Ki=40 nM). | ||
| M13872 | Ocaperidone | 5-HT Receptor |
| R79598 | ||
| Ocaperidone is an effective antipsychotic agent, acting as a potent 5-HT2 and dopamine D2 antagonist, and a 5-HT1A agonist, with Kis of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for 5-HT2, a1-adrenergic receptor, dopamine D2, histamine H1 and a2-adrenergic receptor, respectively. | ||
| M14073 | ATWLPPR Peptide TFA | Complement System |
| ATWLPPR Peptide TFA, a heptapeptide, acts as a selective neuropilin-1 inhibitor, inhibits VEGF165 binding to NRP-1, used in the research of angiogenesis. | ||
| M14810 | Elabela(19-32) | Apelin Receptor |
| Elabela(19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart. | ||
| M14811 | Elabela(19-32) TFA | Apelin Receptor |
| Elabela(19-32) TFA is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) TFA activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) TFA induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart. | ||
| M21163 | Decapeptide-12 | Others |
| Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with the C-terminal residue of tyrosinase (Kd: 61.1 μM). decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 µM ). Sequence: YRSRKYSSWY. | ||
| M24743 | Nogapendekin alfa | IL Receptor/Related |
| Nogapendekin alfa is a superagonist of IL-15. Nogapendekin alfa promotes the proliferation and viability of immune cells. Nogapendekin alfa combines with Inbakicept at a ratio of 2:1, to form ALT-803, an IL-15 cytokine antibody fusion protein. ALT-803 reduces tumor burden by activation of NK cells and CD8+ T cells. | ||
| M25564 | Substance P (6-11) | Neurokinin Receptor |
| Substance P (6-11) is the C-terminal hexapeptideamide of Substance P. Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect. | ||
| M28632 | CMF019 | Others |
| CMF019 is a potent and small molecule agonist at Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ with pKi values of 8.58, 8.49 and 8.71 for human, rat, and mouse, respectively. CMF019 mimics the beneficial cardiovascular actions of apelin in rodents. Apelin receptor (APJ) is a G protein-coupled receptor (GPCR) activated by the endogenous peptide apelin. | ||
| M30094 | Vapendavir | Anti-infection |
| BTA798 | ||
| Vapendavir (BTA798) is a potent enteroviral capsid binder (CB). Vapendavir (BTA798) possesses potent antiviral activity for enterovirus 71 (EV71) replication, with EC50 values of 0.5-1.4 μM in different EV71 strains. | ||
| M30213 | AR03 | DNA/RNA Synthesis |
| BMH-23 | ||
| AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC50 of 2.1 µM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells. | ||
| M30291 | Resolvin E1 | Metabolite/Endogenous Metabolite |
| RvE1 | ||
| Resolvin E1 (RvE1), a potent endogenous pro-resolving mediator of inflammation, is derived from omega-3 fatty acid eicosapentaenoic acid (EPA). Resolvin E1 is endogenously biosynthesized from EPA in the presence of Aspirin during the spontaneous resolution phase of acute inflammation, where specific cell-cell interactions occur. Resolvin E1 possesses unique counterregulatory actions that inhibit polymorphonuclear leukocyte (PMN) transendothelial migration. Resolvin E1 also acts as a potent inhibitor of leukocyte infiltration, dendritic cell migration, and IL-12 production. | ||
| M40914 | Rivulariapeptolides 1155 | Serine/Threonine Protease |
| Rivulariapeptolides 1155 is a potent serine protease inhibitor with IC50 values of 41.84 nM, 4.94 nM, and 56.54 nM for chymotrypsin, elastase, and proteinase K, respectively. | ||
| M40916 | Rivulariapeptolides 1185 | Serine/Threonine Protease |
| Rivulariapeptolides 1185 is a potent and selective serine protease inhibitor with IC50 values of 13.17 nM, 23.59 nM, and 55.26 nM for tryptic coagulase, elastase, and proteinase K, respectively. | ||
| M40917 | Rivulariapeptolides 1121 | Serine/Threonine Protease |
| Rivulariapeptolides 1121 is a potent and selective serine protease inhibitor with IC50 values of 35.52 nM, 13.24 nM, and 48.05 nM for tryptic coagulase, elastase, and proteinase K, respectively. | ||
| M53093 | Nonapeptide-1 | Melanocortin Receptor |
| Nonapeptide-1 (Melanostatine-5), a peptide hormone, is a selective antagonist of MC1R (Ki: 40 nM). | ||
| M54252 | Fibrinogen Binding Inhibitor Peptide | Others |
| Fibrinogen Binding Inhibitor Peptide is a dodecapeptide (HHLGGAKQAGDV, H12), which is a fibrinogen γ-chain carboxy-terminal sequence (γ400-411). | ||
| M55213 | Zanapezil | AChR/AChE |
| TAK-147; Zanapezil free base | ||
| Zanapezil (TAK-147) is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor, it has potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM). | ||
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