About 24 results found for searched term "AP39" (0.123 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M14653 | AP39 | Mitochondrial Related |
| AP39 is a triphenylphosphonium derivatised anethole dithiolethione and mitochondria-targeting hydrogen sulfide (H2S) donor. | ||
| M50915 | apoB (4372-4392) | Others |
| apoB (4372-4392) is a potent lipoprotein(a) assembly inhibitor, with an IC50 of 40 μM. | ||
| M1727 | Apitolisib (GDC-0980) | PI3K |
| RG7422; GNE 390 | ||
| Apitolisib (GDC-0980; GNE 390; RG 7422) is a potent, highly selective, oral, dual inhibitor of class I PI3K and mTOR. | ||
| M1921 | Mizoribine | DNA/RNA Synthesis |
| Bredinin | ||
| Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM. Mizoribine inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively. | ||
| M2945 | Pimozide | Dopamine Receptor |
| R6238 | ||
| Pimozide is an antagonist of 6-hydroxyapatide against 6-hydroxyapatide, with Ki values of 1.4 nM, 2.5 nM and 588 nM for 6-hydroxyapatide, D3 and D1 receptors, respectively. Pimozide also has a high affinity for α1-adrenoceptor. Ki value is 39 nM. Pimozide is also an inhibitor of STAT3 and STAT5, and piperimidate triggers ADCD in glioblastoma cell lines (LN-229, MZ-54, GOS-3 and U343) by inducing dephosphorylation and inactivation of mTORC1. | ||
| M1596 | Apigenin 7-O-glucuronide | MMP |
| Apigenin-7-glucuronide | ||
| Apigenin 7-O-glucuronide is an inhibitor of Matrix Metalloproteinases (MMP) with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively. | ||
| M6128 | BOC-D-FMK | Caspase |
| Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 µM. | ||
| M7182 | RA 839 | Keap1-Nrf2 |
| RA839 | ||
| RA 839 is a nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 6 μM). RA 839 suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Anti-inflammatory. | ||
| M7582 | SB 239063 | p38 MAPK |
| SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. | ||
| M10952 | BRD0639 | PRMTs |
| BRD0639 is a first-in-class inhibitor of PRMT5-substrate aptamer interactions.BRD0639 is a PRMT5-binding motif (PBM) competitor that supports studies of PBM-dependent PRMT5 activity. | ||
| M11348 | Garcinol | AChR/AChE |
| Garcinol is a kind of polyisoprene diphenylketone extracted from Garcinia japonicum. It has anticholinesterase properties for AChE and butyrylcholinesterase (BChE) with IC50 of 0.66 µM and 7.39 µM, respectively. Garcinol also inhibited histone acetyltransferases (HATs, IC50=7 μM) and P300 /CPB related factors (PCAF, IC50=5 μM). Garcinol has anti-inflammatory and anticancer activities. | ||
| M13548 | SM-164 Hydrochloride | IAP |
| SM-164 Hydrochloride is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains with an IC50 value of 1.39 nM and functions as an extremely potent antagonist of XIAP. | ||
| M15061 | Atuliflapon | Lipoxygenase |
| AZD5718 | ||
| Atuliflapon (AZD5718) is a 5-lox activating protein (FLAP, 5‑Lipoxygenase activating protein) inhibitor that attenuates the 5-lipoxygenase pathway and reduces pro-inflammatory and vasoactive leukotriene (LT) production at an in vitro maximum 50% inhibitory concentration (IC50) of 39nM. | ||
| M21942 | Balovaptan | Vasopressin Receptor |
| RG7314 | ||
| Balovaptan (RG7314) is an orally available, selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors. | ||
| M24887 | Torapsel | Others |
| 42-89-glycoprotein; WAY164339; pMT21:PL85 | ||
| Torapsel (42-89-glycoprotein; WAY164339) is a fusion protein with immunoglobiln. Torapsel can be used to research the prevention of ischemia reperfusion injury. | ||
| M29182 | Rpn11-IN-1 | Proteasome |
| Capzimin intermediate | ||
| Rpn11-IN-1 (Capzimin intermediate) is a potent and selective inhibitor of proteasome subunit Rpn11 with an IC50 of 390 nM. | ||
| M29932 | AZ10397767 | CXCR |
| AZ10397767 is an orally active, selective CXCR2 receptor antagonist with an IC50 of 1 nM. AZ10397767 attenuates the Oxaliplatin-induced NF-κB transcriptional activity and potentiates Oxaliplatin-induced apoptosis in androgen-independent prostate cancer (AIPC) cells. AZ10397767 significantly inhibits neutrophil recruitment into tumors which then adversely affects tumor growth in vitro and in vivo. | ||
| M30105 | HDMAPP triammonium | TNF Receptor |
| HDMAPP triammonium is a potent phosphoantigen in the ammonium form and the pyrophosphate form of (E)-HDMAPP. HDMAPP is also a potent activator of γδ T cells and can induce T cell stimulation in vitro (EC50=0.39 nM, TNF-α). | ||
| M38981 | 5,7,8-Trimethoxyflavone | NO Synthase |
| 5,7,8-Trimethoxyflavone (Norwogonin 5,7,8-trimethyl ether), isolated from Andrographis echioides, inhibits NO with an IC50 of 39.1 μM. 5,7,8-Trimethoxyflavone has anti-inflammatory activity. | ||
| M41164 | HEC72702 | Anti-infection |
| HEC72702 is a potent and orally active hepatitis B virus capsid inhibitor with an EC50 values of 0.039 µM. | ||
| M42567 | Motapizone | PDE |
| Motapizone (NAT 05-239) is a selective PDE3 inhibitor. | ||
| M45080 | Fura-FF pentapotassium | Fluorescent Dye |
| Fura-FF pentapotassium is a low affinity calcium fluorescent dye (Ex/Em: 365/514 nm, no calcium; 339/507 nm, high calcium). | ||
| M54120 | Obestatin(human) | Others |
| Obestatin(human) is a 23-amino acid amidated peptide that regulates appetite and gastrointestinal motility via its interaction with GPR39. | ||
| M55625 | XRD-0394 | ATM/ATR |
| XRD0394 | ||
| XRD-0394 is a potent and specific, orally bioavailable dual inhibitor of ATM and DNA-PKcs. XRD-0394 significantly enhanced tumor cell kill in the setting of therapeutic ionizing irradiation in vitro and in vivo. XRD-0394 also potentiates the effectiveness of topoisomerase I inhibitors in vitro. | ||
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