About 3 results found for searched term "ALV1" (0.143 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3483 | Flavopiridol hydrochloride | CDK |
| NSC 649890 HCl; Alvocidib hydrochloride; L86 8275 HCl; HMR-1275 HCl | ||
| Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. | ||
| M5516 | Ciclesonide | GCR |
| Ciclesonide, Alvesco, Omnaris, RPR251526, Zetonna | ||
| Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. | ||
| M66343 | ALV1 | Molecular Glues |
| ALV1 is a molecular glue degrader for Ikaros (IKZF1) and Helios (IKZF2) with DC50 of 2.5 nM and 10.3 nM respectively. ALV1 bind CRBN with an IC50 of 0.55 μM, and induces CRBN-Helios dimerization. | ||
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