About 33 results found for searched term "ALK-IN-1" (0.067 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M5309 | ALK-IN-1 | ALK |
| ALK-IN-1 is an analog of AP26113 which is a potent and selective ALK inhibitor. It is also an inhibitor of EGFR. | ||
| M14877 | ALK inhibitor 1 | ALK |
| ALK inhibitor 1 (compound 17) is a potent pyrimidin ALK inhibitor. ALK inhibitor 1 is a potent inhibitor of testis-specific serine/threonine kinase 2 (TSSK2; IC50=31 nM) and focal adhesion kinase (FAK; IC50=2 nM). | ||
| M28499 | ALK kinase inhibitor-1 | ALK |
| ALK kinase inhibitor-1 is an anaplastic lymphoma kinase (ALK) inhibitor. | ||
| M43106 | GALK1-IN-1 | Others |
| GALK1-IN-1 is a galactokinase inhibitor (IC50: 4.2129 μM). | ||
| M1743 | X-376 | ALK |
| X-376 is a potent and highly specific ALK small molecule tyrosine kinase inhibitor with IC50 of 0.61 nM. | ||
| M1942 | CH5424802 | ALK |
| Alectinib; AF802 | ||
| CH5424802 is a highly selective, orally active and potent ALK inhibitor with IC50 of 1.9 nM. | ||
| M2075 | LDK378 | ALK |
| Ceritinib | ||
| LDK378 is a highly selective, orally bioavailable ALK inhibitor with IC50 of 0.15 nM. | ||
| M2108 | SB-525334 | TGF-β Receptor |
| SB-525334 is a potent activin receptor-like kinase (ALK5)/ type I TGFβ-receptor kinase inhibitor with IC50 of 14.3 nM. | ||
| M2199 | Camptothecin | Topoisomerase |
| Camptothecine; (S)-(+)-Camptothecin; CPT | ||
| Camptothecin (CPT), an alkaloid, is an inhibitor of DNA Topoisomerase I (Topo I) with an IC50 value of 679 nM. Camptothecin (CPT) has strong antitumor activity against colorectal cancer, breast cancer, lung cancer and ovarian cancer, and modulates hypoxia-inducible factor-1α (HIF-1α) activity by altering miRNA expression patterns in human cancer cells. | ||
| M2550 | SB-505124 | TGF-β Receptor |
| Sb-505124 is a selective inhibitor of TGF-βI receptor (ALK4, ALK5, ALK7) with IC50 values of 129 nM and 47 nM for ALK4 and ALK5, respectively. Sb-505124 also inhibits ALK7, but not ALK1, 2, 3 and 6. | ||
| M2859 | ML347 | ALK |
| LDN 193719 | ||
| ML347 is a selective BMP receptor inhibitor with IC50 of 32 nM for ALK2, >300-fold selectivity over ALK3. Also inhibits ALK1 activity with IC50 of 46 nM. | ||
| M2888 | Noscapine hydrochloride | Microtubule |
| Noscapine, a phthalideisoquinoline alkaloid constituting 1–10% of the alkaloid content of opium, has been used as a cough suppressant. | ||
| M3273 | Carmustine | DNA Alkylator/Crosslinker |
| NSC-409962 | ||
| Carmustine is an alkylating antineoplastic agent for inhibiting the growth of U87MG glioblastoma cells with IC50 of 1.42 μM. | ||
| M3781 | NVP-TAE684 | ALK |
| NVP-TAE684 is a highly potent and selective small-molecule ALK inhibitor, which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC(50) values between 2 and 10 nM. | ||
| M3889 | LDN-214117 | ALK |
| LDN-214117 is a potent and selective ALK2 inhibitor with IC50 of 22 nM and >100 fold selectivity for ALK5. | ||
| M3975 | Lorlatinib (PF-06463922) | ALK |
| PF-06463922 | ||
| Lorlatinib (PF-06463922) is an oral active, selective, brain osmotic and ATP-competitive ROS1/ALK inhibitor. The Ki of Lorlatinib for ROS1, wild-type ALK and ALK(L1196M) were <0.025 nM, <0.07 nM and 0.7 nM, respectively. Lorlatinib has anticancer activity. | ||
| M4030 | Crassicauline-A | Others |
| Crassicaulin A | ||
| Crassicauline A (Crassicaulin A) is A bioactive alkaloid in aconite roots. Crassicauline A (Crassicaulin A) had antifeedant activity against the adult Raptor, and its EC50 value was 1134.5 PPM. | ||
| M4228 | Neferine | NF-κB |
| (-)-Neferine | ||
| Neferine is a bisbenzylisoquinoline alkaloid extracted from Plumbago officinalis, which reduces lipid accumulation and promotes β-oxidation through activation of the AMPK pathway in hepatocytes, and possesses anti-inflammatory, antioxidant, and antipulmonary fibrosis activities. In addition, Neferine potently inhibits NF-κB activation.The affinity Kd value of Neferine for ABCB1 is 0.659 μM.It can be used in studies related to non-alcoholic steatohepatitis (NASH). | ||
| M4403 | Groenlandicine | Topoisomerase |
| Groenlandicine is a proto berberine alkaloid isolated from coptis chinensis. Groenlandicine has moderate inhibition of human recombinant aldose reductase (HRAR) with an IC50 value of 154.2 μM. Groenlandicine induces DNA cleavage mediated by topoisomerase I. | ||
| M4458 | Tetrahydroberberine | Dopamine Receptor |
| Canadine; THB | ||
| Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber; has micromolar affinity for dopamine D(2) (pK(i) = 6.08) and 5-HT(1A) (pK(i) = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors (5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK(i) < 5.00). | ||
| M4520 | (+)-Corydaline | AChR/AChE |
| (+)-Corydaline; Corydalin | ||
| Corydaline ((+) -corydaline) is an isoquinoline alkaloid extracted from Corydalis Yanhusuo. It is an inhibitor of AChE with IC50 of 226 µM. Corydaline is a μ-opioid receptor agonist (Ki = 1.23 µM) that inhibits the replication of enterovirus 71 (EV71) (IC50 = 25.23 µM). Corydaline has anti-angiogenesis, anti-allergy, gastric emptying and anti-nociception effects. | ||
| M4718 | Dendrobine | Anti-infection |
| Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine has antiviral activity against influenza A virus, IC50 values for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2) were 3.39 μM, 2.16 μM and 5.32 μM, respectively. | ||
| M4811 | CH5424802 HCl | ALK |
| AF802 HCl; Alectinib Hydrochloride | ||
| CH5424802 HCl is a potent ALK inhibitor with IC50 of 1.9 nM, sensitive to L1196M mutation. | ||
| M4984 | CEP-37440 | ALK |
| CEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma). | ||
| M5037 | A 83-01 | TGF-β Receptor |
| A83-01; A-83-01 | ||
| A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively).*The compound is unstable in solutions, freshly prepared is recommended | ||
| M5038 | SD-208 | TGF-β Receptor |
| SD208 | ||
| SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII. | ||
| M5161 | Sodium orthovanadate | ATPase |
| Sodium vanadate | ||
| Sodium orthovanadate is an alkaline phosphatase and (Na,K)-ATPase inhibitor with IC50 of 10 μM. | ||
| M5220 | Piperlongumine | Others |
| PPLGM, Piplartine | ||
| Piperlongumine, a natural alkaloid from Piper longum L., is also a direct TrxR1 inhibitor with suppressive activity against gastric cancer and a novel inhibitor of CRM1. | ||
| M5246 | EW-7197 | TGF-β Receptor |
| Vactosertib; TEW-7197 | ||
| EW-7197 is a highly potent, selective, and orally bioavailable TGF-β receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively. | ||
| M5613 | Entrectinib (RXDX-101) | ALK |
| NMS-E628; RXDX-101 | ||
| Entrectinib (RXDX-101) is an orally bioavailable pan-TrkA/B/C, ROS1 and ALK inhibitor with IC50 ranging between 0.1 and 1.7 nM. | ||
| M5881 | Piperine | P-glycoprotein |
| Bioperine; 1-Piperoylpiperidine | ||
| Piperine, a natural alkaloid isolated from Piper nigrum L, inhibits P-glycoprotein and CYP3A4 activities with an IC50 value of 61.94±0.054 μg/mL in HeLa cell. | ||
| M6159 | GSK-2018682 | LPL Receptor |
| This compound belongs to the class of organic compounds known as n-alkylindoles. These are compounds containing an indole moiety that carries an alkyl chain at the 1-position. | ||
| M6168 | Ceritinib (LDK378) dihydrochloride | ALK |
| Ceritinib dihydrochloride | ||
| Ceritinib dihydrochloride (LDK378 dihydrochloride) is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively. | ||
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
