About 25 results found for searched term "AD80" (0.129 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1781 | Adezmapimod (SB203580) | p38 MAPK |
| RWJ 64809; PB 203580; Adezmapimod | ||
| Adezmapimod (SB203580) is a P38 MAPK inhibitor with an IC50 of 0.3-0.5 μM, which is 10 times less selective than SAPK3(106T) and SAPK4(106T), and inhibits PKB phosphorylation with an IC50 of 3-5 μM. | ||
| M7249 | SB 203580 hydrochloride | p38 MAPK |
| Adezmapimod hydrochloride ; RWJ 64809 hydrochloride | ||
| SB 203580 hydrochloride is a selective inhibitor of p38 MAPK; water-soluble. | ||
| M10375 | AD80 | RET |
| AD-80 | ||
| AD80 is a multikinase inhibitor, it potently targets human RET, BRAF, S6K, and SRC. | ||
| M21331 | Recombinant Human CDH1 (HEK293, C-6His) | Cytokines and Growth Factors |
| Cadherin-1; CDH1;CAM 120/80;E-cadherin; CD324 | ||
| Recombinant human Cadherin-1/E-Cadherin/CDH1 is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. Accession: P12830. | ||
| M2090 | MLN2480 | Raf |
| BIIB-024; Tovorafenib | ||
| MLN2480 is an orally active, CNS-permeable, highly selective inhibitor of type II RAF kinase that inhibits both monomeric (class I mutant) and dimeric forms of RAF and does not cause aberrant activation of the MAPK pathway caused by type I RAF inhibitors. In addition, MLN2480 inhibits the growth of tumors harboring BRAF fusions or BRAF V600 mutations and can be used in studies related to gliomas. | ||
| M3264 | Pravadoline | COX |
| WIN 48098 | ||
| Pravadoline (WIN 48098) is a cyclooxygesase inhibitor and inhibits prostaglandin synthesis with IC50 of 4.9 μM, also a cannabinoid agonist. | ||
| M2759 | Darapladib | Phospholipase |
| SB-480848 | ||
| Darapladib (SB-480848) is a selective and orally active inhibitor of Lp-PLA2 with IC50 of 0.25 nM. | ||
| M6767 | GS 6201 | Adenosine Receptor |
| GS 6201 is a selective antagonist of adenosine A2B receptors (Ki values are 22, 1070, 1940 and 3280 nM for human A2B, A3, A1 and A2A receptors respectively). | ||
| M7579 | Tubercidin | Antibiotic |
| 7-Deazaadenosine | ||
| Tubercidin (7-deazaadenosine), an antibiotic obtained from Streptomyces tubercidicus, inhibits the growth of Streptococcus faecalis (8043) with an IC50 value of 0.02 μM. Tubercidin is a weak inhibitor of adenosine phosphorylase and interferes with the phosphorylation of adenosine and AMP. Tubercidin has antiviral activity. | ||
| M10192 | Seladelpar sodium salt | PPAR |
| MBX-8025; RWJ-800025 sodium salt | ||
| Seladelpar (MBX-8025; RWJ-800025) sodium salt is a selective peroxisome proliferator-activated receptor (SPPAR) -δ receptor agonist. | ||
| M20760 | MYF-01-37 | YAP |
| MYF-01-37 is a novel covalent inhibitor of TEAD targeting Cys380 when incubated with the TEAD2 protein. | ||
| M21156 | BI-3802 | Bcl-2 |
| BI-3802 is a potent degradation of oncogenic transcription factor BCL6 with strong inhibitory effect on target genes and anti-proliferative effect.BI-3802 inhibits the BTB structural domain of BCL6, corresponding to an IC50 value ≤ 3 nM.BI-3802 has anti-tumor activity. | ||
| M21293 | BCPyr | BTK |
| BCPyr is a new candidate BTK degradation agent (DC50 = 800 nM). | ||
| M24847 | Iladatuzumab vedotin | Drug-Linker Conjugates for ADC |
| DCDS-0780A | ||
| Iladatuzumab vedotin (DCDS-0780A) is an antibody-drug conjugate (ADC) containing humanized IgG1 anti-human CD79B monoclonal antibody conjugated to MMAE via a protease labile linker. | ||
| M24944 | Serclutamab talirine | Drug-Linker Conjugates for ADC |
| ABBV-321 | ||
| Serclutamab talirine (ABBV-321) is an EGFR-targeted antibody-drug conjugate (ADC). Serclutamab talirine is consisted of an antibody (AM-1-ABT-806) directed against activated EGFR and a pyrrolobenzodiazepine (PBD) dimer. Serclutamab talirine shows potent antitumor activity. | ||
| M27848 | FGI-106 tetrahydrochloride | Anti-infection |
| FGI-106 tetrahydrochloride is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses. FGI-106 tetrahydrochloride is active against Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 tetrahydrochloride also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC50s of 200 nM and 150 nM, respectively. | ||
| M29759 | SZ-015268 | CDK |
| SZ-015268 is a CDK7 inhibitor with an IC50 of 23.56 nM. SZ-015268 has extremely significant anti-tumor advantages. SZ-015268 inhibits HCC70, OVCAR-3, HCT116 and HCC1806 cells proliferation with IC50s of 33, 80.56, 12.53, and 61.55 nM, respectively. | ||
| M29824 | SZUH280 | PROTAC |
| SZUH280 is a potent and selective PROTAC HDAC8 degrader with a DC50 of 0.58 μM in A549 cells. SZUH280 induces cancer cell apoptosis. SZUH280 hampers DNA damage repair in cancer cells, promoting cellular radiosensitization. | ||
| M30191 | FGI-106 | Anti-infection |
| FGI-106 is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses. FGI-106 is active against Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC50s of 200 nM and 150 nM, respectively. | ||
| M43441 | PROTAC GPX4 degrader-1 | PROTAC |
| PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based GPX4 degrader, with a DC50 of 0.03 μM in HT1080 cells. | ||
| M45081 | Rhodamine B hydrazide | Fluorescent Dye |
| Rhodamine B hydrazide is a good sulfite probe with colorless, non-fluorescent properties, which produces fluorescence intensity dependent on sulfite concentration (5-800 ng/mL; detection limit = 1.4 ng/mL (3σ)). Sulfite reduction solubilizes oxygen and generates superoxide radicals, which bind to Rhodamine B hydrazide to form the fluorescent product Rhodamine B. This fluorescence can be enhanced by Tween 80 surfactant micelles.Rhodamine B hydrazide exhibits maximum absorption at 554 nm and maximum fluorescence emission at 574 nm. Rhodamine B hydrazide has maximum absorption at 554 nm and maximum fluorescence emission at 574 nm. | ||
| M49763 | PF-04802367 | GSK-3 |
| PF-04802367 (PF-367) is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. PF-04802367 shows desirable central nervous system (CNS) properties and potency. | ||
| M50853 | GAD65 (206-220) | Others |
| GAD65 (206-220) is glutamic acid decarboxylase (GAD) 65-derived peptide, corresponding to residues 180-188. | ||
| M57170 | dBRD4-BD1 | PROTAC |
| dBRD4-BD1 is a selective and durable BRD4 degrader with an DC50 value of 280 nM (Dmax=77%). | ||
| M56899 | IR-783 | Fluorescent Dye |
| IR-783 (ADS 780WS) is a near-infrared (NIR) heptamethine cyanine fluorescent probe. | ||
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