About 1 result found for searched term "AC-4-130 " (0.124 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M28939 | AC-4-130 | STAT |
| AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML). | ||
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