About 3 results found for searched term "ABL127" (0.126 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M8279 | ABL127 | Others |
| ABL127 is a potent and selective inhibitor of Protein phosphatase methylesterase-1 (PME-1 or PPME-1). | ||
| M29092 | RS-127445 | 5-HT Receptor |
| RS-127445 is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. RS-127445 shows 1000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites. | ||
| M55647 | (R)-NX-2127 | BTK |
| compound 28 | ||
| (R)-NX-2127 (compound 28) is a first-in-class, orally bioavailable Bruton’s Tyrosine Kinase (Btk) degrader. (R)-NX-2127 mediates the degradation of transcription factors IKZF1 and IKZF3 through molecular glue interactions with the cereblon E3 ubiquitin ligase complex. NX-2127 degrades common BTK resistance mutants, including BTKC481S. | ||
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