About 6 results found for searched term "ABCG2-IN-2" (0.183 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42163 | ABCG2-IN-2 | BCRP/ABCG2/MXR/ABCP |
| ABCG2-IN-2 is a potent ABCG2 inhibitor with favorable oral pharmacokinetic profiles in mice. | ||
| M9889 | PCI-29732 | BTK |
| PCI29732 | ||
| PCI-29732 is a potent, reversible BTK inhibitor with Kiapp values of 8.2, 4.6, and 2.5 nM for BTK, Lck, and Lyn, respectively, and has only modest inhibitory activity against Itk, another Tec family kinase. In addition, PCI 29732 inhibits the function of ABCG2 by competitively binding to the ATP binding site of ABCG2. | ||
| M30477 | 6,8-Diprenylnaringenin | BCRP/ABCG2/MXR/ABCP |
| Lonchocarpol A; Senegalensin | ||
| 6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and 3H-Methotrexate transport (IC50=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin. | ||
| M42162 | ABCG2-IN-1 | BCRP/ABCG2/MXR/ABCP |
| ABCG2-IN-1 is an orally active ABCG2 inhibitor with an IC50 of 0.13 μM. | ||
| M49909 | ML230 | BCRP/ABCG2/MXR/ABCP |
| CID44640177; SID 88095709 | ||
| ML230 is a selective inhibitor of the ATP-binding transporter subtype ABCG2, and its inhibitory effect on ABCG2 was 36 times that of ABCB1, with EC50 values of 0.13 μM and 4.65 μM, respectively. | ||
| M49911 | CCTA-1523 | BCRP/ABCG2/MXR/ABCP |
| CCTA-1523 is a potent, selective, reversible, and orally active ABCG2 inhibitor.CCTA-1523 exhibits cytotoxicity and anticancer activity. | ||
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