About 14 results found for searched term "A-485" (0.406 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3368 | AS-604850 | PI3K |
| AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 250 nM, over 80-fold selectivity for PI3Kγ than PI3Kδ/β, and 18-fold more selective for PI3Kγ than PI3Kα. | ||
| M9561 | A-485 | Histone Acetyltransferase |
| A-485 is a potent and selective HAT inhibitor of p300/CBP in vitro with an IC50 of 10 nM in a p300 TR-FRET assay and 3 nM in a CBP TR-FRET assay with selectivity > 1000-fold over closely related HATs. | ||
| M20109 | WAY-325485 | Others |
| WAY-325485 altering the lifespan of a eukaryotic organism | ||
| M51557 | BACE1 (485-501) | Others |
| BACE1 (485-501) is the carboxyl terminal of BACE1 (Beta-site APP cleaving enzyme 1). | ||
| M1824 | SRT1720 Hydrochloride | Sirtuin |
| SRT-1720 Hydrochloride | ||
| SRT1720 Hydrochloride is a selective small molecule activator of SIRT1 that is 1,000-fold more potent than resveratrol (EC1.5 = 0.16 versus 46.2 µM, respectively). SRT1720 increased the activity of SIRT1 and AMPKα phosphorylation at Ser485 via the cAMP-protein kinase A (PKA) pathway. | ||
| M10602 | Necrostatin 2 racemate | RIPK |
| Nec-1s; Necrostatin 1S; 7-Cl-O-Nec-1 | ||
| Necrostatin-2 racemate (also known as 7-Cl-O-Nec-1 and Nec-1s) is a potent and specific receptor-interacting protein kinase 1 (RIPK1) inhibitor lacking the IDO-targeting effect, with >1000-fold more selective for RIPK1 than for any other kinase out of 485 human kinases. | ||
| M13784 | Fluorescein di(β-D-galactopyranoside) | Fluorescent Dye |
| FDG | ||
| Fluorescein di(β-D-galactopyranoside) is a fluorogenic substrate for β-galactosidase (λex=485 nm, λem=535 nm). | ||
| M21072 | Recombinant Mouse GDNF (CHO) | Recombinant Proteins |
| Glial-Derived Neurotrophic Facto; ATF-1 | ||
| Glial neurotrophic factor, also known as GDNF and ATF-1, is a neurotrophic factor belonging to the TGF-β family. ed50 < 8.0 μg/ml, measured in a bioassay using C6 cells. Accession # P48540. | ||
| M25460 | Zasocitinib | JAK |
| NDI-034858; TAK-279 | ||
| Zasocitinib (NDI-034858) is a highly selective, orally active TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of <200 pM. | ||
| M28479 | VU0467485 | AChR/AChE |
| AZ13713945 | ||
| VU0467485 (AZ13713945) is a potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulator (PAM). VU0467485 (AZ13713945) potentiates activity of ACh at M4 with EC50s of 26.6 nM and 78.8 nM at rat and human M4 receptors, respectively. VU0467485 (AZ13713945) shows selectivity for M4 over human and rat M1/2/3/5. VU0467485 (AZ13713945) displays moderate to high CNS penetration. VU0467485 (AZ13713945) has antipsychotic-like activity. | ||
| M28682 | PF-5274857 hydrochloride | Smo |
| PF-5274857 hydrochloride is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-5274857 hydrochloride has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway. | ||
| M29339 | SB-284851-BT | p38 MAPK |
| SB-284851-BT is an inhibitor of BRD4/p38α/BRDT. SB-284851-BT inhibits BRD4-BD1 (IC50=1.7 µM), p38α (Kd=0.47 nM), BRDT (1) (IC50=18 µM) and BRD4 (1)(IC50=3.7 µM). SB-284851-BT reduces IL-8 production by inhibiting p38α, as well as inhibiting BRD4 to down-regulates c-Myc and NF-κB gene pathways in cancer. SB-284851-BT can combined with the bromine domain and extra terminal (BET). | ||
| M41741 | Dehydroaripiprazole hydrochloride | 5-HT Receptor |
| Dehydroaripiprazole (OPC-14857) hydrochloride is an active metabolite of Aripiprazole. | ||
| M49631 | Tyk2-IN-3 | JAK |
| Tyk2-IN-3 is a Tyk2 pseudokinase inhibitor, with an IC50 of 485 nM. | ||
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