About 1 result found for searched term "896705-16-1" (0.123 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3892 | BMH-21 | DNA/RNA Synthesis |
| BMH-21 is a first-in-class DNA intercalator that binds to high-frequency GC-rich sequences in ribosomal DNA genes and can effectively and rapidly inhibit the transcription of RNA polymerase I (Pol I), leading to degradation of the Pol I catalytic subunit RPA194 and non-phosphorylation of histone H2AX. H2AX is not phosphorylated.BMH-21 has broad and potent antitumor activity in NCI60 cancer cell line and inhibits tumor growth in vivo. | ||
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