About 1 result found for searched term "864249-60-5" (0.129 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M6434 | AMG 548 | Casein Kinase |
| AMG 548 is an orally potent and selective inhibitor of p38α (Ki=0.5 nM), slightly selective for p38β (Ki=36 nM) and >1000-fold selective for p38γ and p38δ. In addition, AMG 548 also potently inhibited whole blood LPS-stimulated TNFα (IC50=3 nM) and inhibited Wnt signaling through direct inhibition of Casein kinase 1 isoforms δ and ε. | ||
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