About 6 results found for searched term "77-53-2" (0.119 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M6353 | 6bK | Others |
| 6bK is a insulin degrading enzyme (IDE) inhibitor. | ||
| M17603 | Cedrol | Cytochrome P450 (e.g. CYP17) |
| Cedrol is a potent competitive inhibitor of cytochrome P-450 (CYP) enzymes. Cedrol inhibits CYP2B6-mediated bupropion hydroxylase and CYP3A4-mediated midazolam hydroxylation with Ki of 0.9 μM and 3.4 μM, respectively. Cedrol also has weak inhibitory effect on CYP2C8, CYP2C9, and CYP2C19 enzymes. | ||
| M40390 | Corylifol C | Others |
| Corylifol C is a potent protein kinase inhibitor with IC50 valueS of 8.7, 3.0, 2.1, 6.4, 4.5, 6.2, 2.3, 1.2, 5.1 μg/ml for ARK5, Aurora-A, Aurora-B, AXL, B-RAF-VE, CDK4/CycD1, TIE2, EGF-R, EPHB4, respectively. | ||
| M20808 | ML277 | Potassium Channel |
| CID-53347902 | ||
| ML277 (CID-53347902) is a potent activator of KCNQ1 channels with an EC50 of 260 nM and shows >100-fold selectivity over KCNQ2 and KCNQ4. | ||
| M21153 | MG-277 | PROTAC |
| MG-277 is a molecular gel degrader that efficiently induces degradation of the translation termination factor GSPT1 based on Cereblon E3 ligands with a DC50 of 1.3 nM. MG-277 inhibits tumor cell growth in a non-p53 manner with an IC50 of 3.5 nM and 3.4 nM for RS4;11 cells and p53 mutant RS4;11/IRMI-2 cells, respectively. MG-277 exhibited potent anticancer activity. | ||
| M30058 | YM-1 | HSP |
| YM-1 is a stable and soluble MKT-077 analog and an orally active Hsp70 inhibitor. YM-1 induces cell death of HeLa cells and up-regulates the level of p53 and p21 proteins. | ||
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