About 12 results found for searched term "77-36-1" (0.123 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1951 | Ambrisentan | Endothelin Receptor |
| BSF 208075; LU 208075 | ||
| Ambrisentan is an orally active, highly selective antagonist of the endothelin-1 type A receptor. | ||
| M2513 | Chlorthalidone | Sodium Channel |
| Chlortalidone | ||
| Chlorthalidone is a thiazide-like diuretic, it has potential for the research of hypertension. | ||
| M1764 | PF-477736 | Checkpoint |
| PF-0044736 | ||
| PF-477736 is a selective checkpoint kinase 1 (Chk1) inhibitor with Ki values of 0.49 nM and 47 nM for CHK1 and CHK2 respectively. | ||
| M1779 | SGI-1776 | Pim |
| SGI-1776 is novel small molecule inhibitor of PIM kinase activity with IC50 of 7 ± 1.8, 363 ± 27.6 and 69 ± 9.2 nM for Pim-1, Pim-2, and Pim-3, respectively. | ||
| M6372 | A 77636 hydrochloride | Dopamine Receptor |
| A 77636 hydrochloride is a potent, selective D 1-like agonist. Orally active. | ||
| M20633 | TP0427736 HCl | Src-bcr-Abl |
| TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. | ||
| M20705 | AS2863619 | CDK |
| AS2863619 is a small-molecule cyclin-dependent kinase CDK8/19 inhibitor with IC50 of 0.6099 nM and 4.277 nM, respectively. AS2863619 is a potent Foxp3 inducer in Tconv cells. | ||
| M28961 | TH1217 | Anti-infection |
| ZINC1775962367 | ||
| TH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19. | ||
| M29265 | PSB 0777 ammonium | Adenosine Receptor |
| PSB 0777 ammonium is a potent and selective adenosine A2A receptor full agonist with Ki values of 44.4 nM, 360 nM for rat and human A2A receptors, respectively. PSB 0777 ammonium has Ki values of ≥10000 nM, 541 nM for rat and human A1 receptors, respectively. PSB 0777 ammonium shows poor brain penetrant and perorally non-absorbable effect. PSB 0777 ammonium has the potential for inflammatory bowel disease (IBS) research research. | ||
| M29386 | CCT367766 | PROTAC |
| CCT367766 is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein. | ||
| M30602 | A-77636 | Dopamine Receptor |
| A-77636 is an orally active, potent, selective and long-acting dopamine D1 receptor agonist (pEC50 = 8.13; EC50 = 1.1 nM). A-77636 shows the highest affinity (pKi = 7.40 ± 0.09; Ki = 39.8 nM) for the dopamine D1 receptor. A-77636 shows antiparkinsonian activity. | ||
| M31074 | CCT367766 formic | PROTAC |
| CCT367766 formic is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 formic exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 formic reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. | ||
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