About 1 result found for searched term "683808-78-8" (0.163 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M30482 | Poloppin | PLK |
| Poloppin is a potent, cell penetrant inhibitor of the mitotic Polo-like kinase (PLK) (IC50=26.9 μM) and prevents the protein-protein interaction via the Polo-box domain (PBD) (Kd= 29.5 μM). Poloppin selectively kills cells expressing mutant KRAS, enhancing death in mitosis. Poloppin is used for the study of KRAS-mutant cancers as single agents, or in combination with c-MET inhibitors. | ||
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