About 8 results found for searched term "61-80-3" (0.125 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3142 | Zoxazolamine | Cytochrome P450 (e.g. CYP17) |
| Zoxazolamine is a centrally acting myorelaxant.It is formerly used as an antispasmodic and uricosuric. | ||
| M7666 | BMS-199264 hydrochloride | Others |
| BMS-199624 is a potent inhibitor of the ATP hydrolase activity of mitochondrial F1F0 ATP synthase. | ||
| M21144 | JNJ-61803534 | Others |
| JNJ-61803534 is an orally active RORgt inhibitor, JNJ-61803534 is an oral clinical candidate that is well tolerated in humans up to 200 mg and has shown PD. | ||
| M29017 | JNJ-61803534 | ROR |
| JNJ-61803534 is a potent and orally active RORγt inverse agonist with an IC50 of 9.6 nM. JNJ-61803534 has anti-inflammatory activity. JNJ-61803534 inhibits IL-17A production in human CD4+ T cells under Th17 differentiation conditions. | ||
| M3736 | Ro 61-8048 | Others |
| Ro 61-8048 is a potent and selective inhibitors of kynurenine hydroxylase with IC50 of 37 nM that increases kynurenic acid levels and reduces extracellular glutamate in the brain. | ||
| M4891 | Ns6180 | Potassium Channel |
| AOB1491 | ||
| NS6180 is a highly selective inhibitor of KCa3.1 ion channels with an IC50 value of 9nM, blocking T cell activation and inflammatory response. | ||
| M28716 | ML380 | AChR/AChE |
| ML380 is a potent, subtype-selective, and brain-penetrant positive allosteric modulator (PAM) of M5 mAChR, with EC50s of 190 and 610 nM for human and rat M5, respectively. ML380 exhibits moderate selectivity versus the M1 and M3 mAChR subtypes. ML380 could increase the affinity of ACh for the M5 mAChR. | ||
| M49626 | TK4g | JAK |
| TK4g is a Janus kinase (JAK) inhibitor with the IC50 values of 12.61 nM and 15.80 nM for JAK2 and JAK3, respectively. | ||
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