About 11 results found for searched term "6-Me-ATP" (0.124 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M43382 | 6-Me-ATP | GSK-3 |
| 6-Me-ATP (N6-Methyl-ATP) is a N6-modified ATP derivative. | ||
| M3737 | Pyridone 6 | JAK |
| Merck-5, CMP 6, JAK Inhibitor I | ||
| Pyridone 6 is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK1 (IC50 = 15 nM for murine JAK1), JAK2 (IC50 = 1 nM), JAK3 (Ki = 5 nM), and Tyk 2 (IC50 = 1 nM) (Janus protein tyrosine kinases). | ||
| M7954 | NP603 | Others |
| NP603 is a cell-permeable inhibitor of PDGFRβ, FGFR1 and VEGFR2 that binds to ATP pocket. | ||
| M8639 | STK16-IN-1 | Others |
| STK16-IN-1 is a cell-permeable pyrrolonaphthyridinone compound that acts as an ATP-competitive inhibitor against NAK (Numb Associated Kinase) family serine/threonine kinase STK16 (IC50/substrate = 0. | ||
| M9274 | SMI-16a | Pim |
| PIM1/2 Kinase Inhibitor VI | ||
| SMI-16a is a potent, cell-permeable, ATP-competitive inhibitor of Pim-1/2 kinases with IC50s of 150 nM and 20 nM against Pim-1 and Pim-2, respectively. | ||
| M11056 | NSC 617145 | DNA/RNA Synthesis |
| NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor,IC50 The value is 230 nM. NSC 617145 inhibit WRN ATPase and induce double-strand rupture (DSB) and chromosomal abnormalities. NSC 617145 is selective to WRN and superior to BLM, FANCJ, ChlR1, RecQ, and UvrD helicases. | ||
| M13623 | Prexasertib dimesylate | Checkpoint |
| LY2606368 dimesylate | ||
| Prexasertib dimesylate (LY2606368 dimesylate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. | ||
| M14169 | GDC-0623 | MEK |
| RG 7421; MEK inhibitor 1 | ||
| GDC-0623 (RG 7421) is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM). | ||
| M14916 | R406 besylate | Syk |
| R406 benzenesulfonate; Tamatinib | ||
| R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. | ||
| M30938 | QM31 | Caspase |
| SVT016426 | ||
| QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint. | ||
| M41463 | H3B-968 | DNA/RNA Synthesis |
| H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) (IC50=~10 nM), which acts function as helicase, ATPase, and exonuclease. | ||
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