About 5 results found for searched term "54-21-7" (0.125 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3024 | Sodium salicylate | COX |
| Salicylic acid sodium salt; 2-Hydroxybenzoic acid sodium salt | ||
| Sodium salicylate is used in medicine as an analgesic and antipyretic. | ||
| M20689 | Sparsentan (RE-021) | Endothelin Receptor |
| PS-433540; RE-021; DARA-a; BMS-346567 | ||
| Sparsentan (PS-433540, RE-021, DARA) is a first-in-class, orally active, high-affinity dual antagonist of the endothelin type A receptor (ETA) and Angiotensin II type 1 (AT1) receptor, with Ki values of 9.3 and 0.8 nM, respectively. | ||
| M28584 | STAD 2 | PKA |
| STAD 2 is a potent and selective disruptor of PKA-RII, with a Kd of 6.2 nM. STAD 2 disrupts interactions between PKA and AKAP in an isoform-selective manner. STAD 2 displays antimalarial activity through a PKA-independent mechanism. | ||
| M28586 | LML134 | Histamine Receptor |
| LML134 (compound 18b) is an orally active and high selective Histamine 3 receptor (H3R) inverse agonist with Kis of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg. LML134 penetrates the brain rapidly, leading to high H3R occupancy, and disengages its target with a fast kinetic profile. LML134 has the potential for excessive sleep disorders. | ||
| M31206 | Bisindolylmaleimide VIII acetate | PKC |
| Ro 31-7549 acetate; Bis VIII acetate | ||
| Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII acetate has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively. | ||
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