About 10 results found for searched term "51-02-5" (0.124 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M30212 | Pronethalol hydrochloride | Adrenergic Receptor |
| (±)-Pronethalo hydrochloride | ||
| Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs). | ||
| M40217 | Demethylcephalotaxinone | Others |
| Demethylcephalotaxinone is an alkaloid. Demethylcephalotaxinone can be isolated from Hainan cycad (C. hainanensis). | ||
| M43525 | SHP2-IN-13 | Phosphatase |
| SHP2-IN-13 is a highly selective and orally active SHP2 “tunnel site” allosteric inhibitor with an IC50 of 83.0 nM. | ||
| M3278 | MK-5172 (Grazoprevir) | HCV Protease |
| Grazoprevir; MK5172 | ||
| MK-5172 is a novel NS3/4, a protease inhibitor for chronic HCV infection (Enzyme Ki for genotype1b, 2a, 2b and 3a at ＜0.02, 0.15, 0.02 and 0.7 nM, respectively). | ||
| M9121 | LY303511 hydrochloride | mTOR |
| NV-128; EM 101 hydrochloride | ||
| LY303511 hydrochloride is a structural analogue of LY294002. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. | ||
| M21389 | JNJ-55511118 | Others |
| JNJ-55511118 is an AMPA receptor negative regulator containing transmembrane AMPA receptor regulatory protein γ8 (TARP-γ8). 1 It inhibits glutamate-induced calcium flux in HEK293F cells that were cotransfected with TARP-γ8 and GluA1o, GluA1i, GluA2i, GluA3o, or GluA4o (IC50s = 11.22, 12.3, 7.41, 38.02, and 15.85 nM, respectively). | ||
| M27703 | Dagrocorat | GCR |
| PF-00251802 | ||
| Dagrocorat (PF-00251802) is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat is also a time-dependent reversible inhibitor of CYP3A (IC50=1.3 μM in human liver microsomes) and CYP2D6 (Ki=0.57 μM in human liver microsomes). Dagrocorat can be used for the research of rheumatoid arthritis. | ||
| M27705 | Dagrocorat hydrochloride | GCR |
| PF-00251802 hydrochloride | ||
| Dagrocorat (PF-00251802) hydrochloride is an orally active and selective high-affinity partial agonist of the glucocorticoid receptor. Dagrocorat hydrochloride is also a time-dependent reversible inhibitor of CYP3A (IC50=1.3 μM in human liver microsomes) and CYP2D6 (Ki=0.57 μM in human liver microsomes). Dagrocorat hydrochloride can be used for the research of rheumatoid arthritis. | ||
| M29859 | UC-514321 | STAT |
| UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity. | ||
| M41796 | PD 135158 | Cholecystokinin Receptor |
| PD 135158 (CAM 1028) is a selective CCKB receptor antagonist with an IC50 of 2.8 nM against mouse cortex CCKB. | ||
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