About 32 results found for searched term "3-AP-Me" (0.065 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M8426 | 3-AP-Me | Others |
| 3-AP-Me is a dimethyl derivative of the ribonucleotide reductase inhibitor 3-AP (SML0568). | ||
| M9028 | Nifuratel | Anti-infection |
| Macmiror; Magmilor; NF 113; SAP 113; Methylmercadone | ||
| Nifuratel is a local antiprotozoal and antifungal agent used in gynecology. | ||
| M1637 | ABT-263 | Bcl-2 |
| Navitoclax | ||
| ABT-263 (Navitoclax) is a potent, orally bioavailable inhibitor of the antiapoptotic Bcl-2 family members Bcl-2, Bcl-x (L), and Bcl-w. | ||
| M58110 | Recombinant Human RIPK3 Protein (E. coli, N-His) | Cytokines and Growth Factors |
| RIP-like protein kinase 3; RIP3 | ||
| RIPK3 is a kinase that controls necroptosis and apoptosis. In necroptosis, activated by TNF-α and ZBP1, RIPK3 phosphorylates MLKL, leading to membrane damage. Necroptosis is dependent on receptor-interacting protein kinase 3 (RIPK3), a protein shown to play an important role in experimental models of critical illness. RIPK3 promotes kidney tubular injury via mitochondrial dysfunction. The FAO-dependent RIPK3 mediates pathogenesis of acute lung injury. | ||
| M1689 | BTZ043 Racemate | Anti-infection |
| BTZ038, BTZ044 | ||
| BTZ043 Racemate (BTZ038, BTZ044) is a decaprenylphosphoryl-b-D-ribose 2-epimerase inhibitor. | ||
| M1765 | Crizotinib (PF-02341066) | c-Met |
| Crizotinib | ||
| Crizotinib (PF-02341066) is a potent, orally bioavailable, ATP-competitive small-molecule inhibitor of c-Met kinase and ALK (anaplastic lymphoma kinase) with IC50 values to be 4 and 25 nM for C-Met and ALK resepectively. | ||
| M1781 | Adezmapimod (SB203580) | p38 MAPK |
| RWJ 64809; PB 203580; Adezmapimod | ||
| Adezmapimod (SB203580) is a P38 MAPK inhibitor with an IC50 of 0.3-0.5 μM, which is 10 times less selective than SAPK3(106T) and SAPK4(106T), and inhibits PKB phosphorylation with an IC50 of 3-5 μM. | ||
| M2166 | Birinapant | IAP |
| TL32711 | ||
| Birinapant (TL32711) is a bivalent Smac analogue, which is a potent antagonist of XIAP and cIAP1 with Kd values of 45 nM and less than 1 nM, respectively. Birinapant (TL32711) induces autoubiquitination and proteasome degradation of cIAP1 and cIAP2 in intact cells, resulting in the formation of RIPK1: Caspase-8 complex, which activates and induces tumor cell death. | ||
| M2403 | MDK83190 | Caspase |
| Apoptosis Activator 2; MDK-83190 | ||
| MDK83190 (Apoptosis Activator 2) strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells. | ||
| M2583 | PD 169316 | p38 MAPK |
| PD 169316 is a cell-permeable, potent and selective p38 MAP kinase inhibitor that indirectly activates proteasome activity and has antiviral activity against Enterovirus71 with an IC50 value of 89 nM. | ||
| M2669 | Entacapone | FTO |
| OR-611 | ||
| Entacapone is an inhibitor of FTO demethylation with IC50 of 3.5 μM, Entacapone also inhibits catechol-O-methyltransferase (COMT) with IC50 of 151 nM. | ||
| M58372 | (S)-LY-3381916 | IDO |
| (S)-IDO1-IN-5 | ||
| (S)-LY-3381916 is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC50 value less than 1.5 µΜ. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1. | ||
| M2733 | GSK2190915 | Lipoxygenase |
| AM-803, Fiboflapon | ||
| GSK2190915 (AM803), a potent FLAP inhibitor, prevents the synthesis of leukotrienes and 5-oxo-ETE, with IC50 of 76 nM for inhibition of LTB4 in human blood, provides treatment for asthma. | ||
| M2800 | KY02111 | Others |
| KY02111 is a widely used small molecule that boosts cardiomyogenesis. Chemical genetics of KY02111 identified squalene synthase (SQS) as a molecular target of KY02111. By disrupting the interaction of SQS with cardiac ER-membrane protein TMEM43, KY02111 impairs TGFβ/SMAD signaling and recapitulates the clinical mutation of TMEM43 that causes an inherited heart disease. | ||
| M2826 | LY2090314 | GSK-3 |
| LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. Phase 1/2. | ||
| M3048 | TAK-715 | p38 MAPK |
| TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. | ||
| M3144 | P7C3 | NAMPT |
| P7C3 is an orally bioavailable and blood-brain barrier penetrant aminopropyl carbazole, with neuroprotective effects. P7C3 exerts its proneurogenic activity by protecting newborn neurons from apoptosis. P7C3 also enhances learning and memory in aged rats. | ||
| M11300 | Recombinant Human Apolipoprotein H/APOH (HEK293, His) | Cytokines and Growth Factors |
| Apolipoprotein H 蛋白, Human (HEK293, His) | ||
| Recombinant human Apolipoprotein H(APOH) protein (HEK293, His) was expressed in HEK293 cells with a His tag on the N-terminal. Apolipoprotein H is the primary target of antiphospholipid antibodies (aPLs) found in many patients with systemic lupus erythematosus and antiphospholipid syndrome (APS). | ||
| M3354 | Carbamazepine | Sodium Channel |
| CBZ; NSC 169864 | ||
| Carbamazepine is a sodium channel inhibitor with an IC50 of 131 μM when treated with synaptosomes in rat brain. It can be used in trigeminal neuralgia research. Carbamazepine blocks voltage gated Na+, Ca2+, and K+ channels, and is also a HDAC inhibitor (IC50=2 μM). | ||
| M3497 | Simvastatin (MK 733) | Autophagy |
| MK 733; MK-0733 | ||
| Simvastatin (MK-0733, MK 733) is a competitive inhibitor of HMG-CoA reductase with Ki of 0.1-0.2 nM in cell-free assays. Simvastatin induces ferroptosis, mitophagy, autophagy and apoptosis. Simvastatin inhibits exosome release. Prior to use in cell assays, Simvastatin needs to be activated by NaOH in EtOH treatment. | ||
| M4182 | Isochlorogenic-acid-B | Anti-infection |
| 3,4-Di-O-caffeoylquinic acid; Isochlorogenic acid B | ||
| 3, 4-dicaffeoylquinic acid is naturally isolated and has antioxidant, DNA protective, neuroprotective and liver protective properties. 3, 4-dicaffeoylquinic acid has apoptosis-mediated cytotoxicity and α-glucosidase inhibition. 3, 4-dicaffeoylquinic acid has a unique antiviral mechanism, that is, by increasing TRAIL, the virus clearance rate can be improved. | ||
| M5297 | Telacebec | Anti-infection |
| Q-203; Q 203; IAP6 | ||
| Telacebec (Q203; IAP6) is a midazopyridine amide compound. Q203 is active against Mycobacterium tuberculosis H37Rv with an MIC50 of 2.7 nM in culture broth medium. | ||
| M5665 | Fotemustine | DNA Alkylator/Crosslinker |
| S10036 | ||
| Fotemustine (S 10036) is a nitrosourea alkylating agent approved for use in the treatment of metastasising melanoma. | ||
| M5715 | Isotretinoin | Others |
| 13-cis-Retinoic acid | ||
| Isotretinoin(13-cis-Retinoic acid) is a medication used for the treatment of severe acne. It was first developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M5772 | Meropenem trihydrate | Antibiotic |
| SM 7338 trihydrate | ||
| Meropenem (SM 7338) trihydrate is a carbapenem antibiotic, which displaying a broad spectrum of antibacterial activity. Meropenem trihydrate has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL). | ||
| M6661 | Deguelin | Akt |
| (-)-Deguelin; (-)-cis-Deguelin | ||
| Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB. | ||
| M7112 | PETCM | Caspase |
| PETCM is a activator of caspase-3. PETCM promotes Apaf-1 oligomerization and induces cell apoptosis in HeLa cells. | ||
| M7323 | SR 11302 | Others |
| SR11302 | ||
| SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE). | ||
| M7627 | BIO | GSK-3 |
| 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime6BIO; GSK 3 IX; GSK 3 Inhibitor IX; MLS 2052 | ||
| BIO (GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052) is a specific GSK-3 inhibitor, the IC50 acting on GSK-3α/β in cell-free assays is 5 nM, which is more than 16 times more selective than ACTing on CDK5. It is also a pan-JAK inhibitor with an IC50 value of 30 nM for Tyk2. BIO induces apoptosis in human melanoma cells. | ||
| M7969 | NS3694 | Others |
| NS3694 is an Inhibitor of apoptosome formation. | ||
| M8078 | PF-06663195 | Others |
| PF-06663195 is a potent inhibitor of β-site amyloid precursor protein (APP) Cleaving Enzyme 1 (BACE1, β-Secretase 1). | ||
| M8392 | Tirapazamine | Apoptosis |
| SR259075; SR4233; Win59075; SML 0552; Tirazone; TPZ | ||
| Tirapazamine (TPZ，SR-4233, WIN 59075) is the first hypoxia-activated prodrug. Tirapazamine kills hypoxic cells by inducing chromosome aberrations and DNA double-strand breaks. Tirapazamine induced cell cycle arrest and apoptosis, and down-regulated HIF-1α, CA-IX and VEGF expression. | ||
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