About 1 result found for searched term "2800223-30-5" (0.402 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M54589 | Dabogratinib | FGFR |
| TYRA-300 | ||
| Dabogratinib (TYRA-300) is an orally active, selective FGFR3 inhibitor with an IC50 of 11 nM. Dabogratinib downregulates the FGFR3 and ERK1/2 signaling pathways, and induces tumor growth inhibition and regression in FGFR3-altered xenograft models. Dabogratinib promotes chondrocyte proliferation and differentiation, drives endochondral bone formation and overall body growth, partially restores long bone proportions, and improves craniofacial and spinal morphology. | ||
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