About 1 result found for searched term "2204290-85-5" (0.157 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M29346 | FzM1.8 | Wnt/beta-catenin |
| FzM1.8 derives from FzM1, is an allosteric agonist of FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 binding stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K. | ||
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