About 1 result found for searched term "2050478-92-5" (0.157 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M24888 | Cetrelimab | PD-1/PD-L1 |
| JNJ 63723283; JNJ 3283 | ||
| Cetrelimab (JNJ 63723283; JNJ 3283) is a humanized IgG4κ mAb targeting PD-1. Cetrelimab binds PD-1 (Kd=1.72 nM, HEK293) to block the interaction of PD-1 with PD-L1 and PD-L2 (IC50s=111.7 ng/mL and 138.6 ng/mL, respectively). Cetrelimab stimulates peripheral T cells, increases IFN-γ, IL-2, TNF-α level and inhibits tumor growth in vivo. | ||
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