About 1 result found for searched term "20α-Hydroxycholesterol" (0.08 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M58641 | 20α-Hydroxycholesterol | Smo |
| 20(S)-Hydroxycholesterol | ||
| 20α-Hydroxycholesterol is an allosteric activator that selectively targets the Smoothened (Smo) of the Hedgehog pathway with an EC50 of ~30 μM (Hedgehog). 20α-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors. 20α-Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells. | ||
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