About 1 result found for searched term "1791416-49-3" (0.125 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M24799 | Elezanumab | TGF-beta/Smad |
| ABT-555; AE12-1Y-QL; Anti-RGMA Reference Antibody | ||
| Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC50 around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism. | ||
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