About 1 result found for searched term "133627-24-4" (0.125 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M28196 | 12-Hydroxynevirapine | Metabolite/Endogenous Metabolite |
| 12-hydroxy-NVP; 12-OH-NVP | ||
| 12-Hydroxynevirapine (12-hydroxy-NVP; 12-OH-NVP) is a major oxidative metabolite of Nevirapine. Nevirapine is a non-nucleoside reverse transcriptase inhibitor indicated for the HIV-1 infections. Nevirapine causes idiosyncratic hepatotoxicity and mild-to-severe skin rashes. 12-Hydroxynevirapine, a non-reactive metabolite, can be bioactivated by sulphotransferases (SULTs) in the liver and skin, yielding the reactive species 12-Sulphoxy-nevirapine. | ||
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