About 1 result found for searched term "1204329-34-9" (0.123 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M27936 | BI-9627 | Na+/H+ Exchanger (NHE) |
| BI-9627 is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury. | ||
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