About 1 result found for searched term "120408-07-3" (0.139 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M27935 | Lometrexol disodium | Antifolate |
| DDATHF disodium | ||
| Lometrexol (DDATHF) disodium, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol disodium can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol disodium has anticancer activity. Lometrexol disodium also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor. | ||
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