About 1 result found for searched term "1199796-29-6" (0.08 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M9055 | INT-777 | GPCR19/TGR5 |
| S-EMCA | ||
| INT-777 is a potent TGR5 agonist with EC50 of 0.82 μM. In animal models, INT-777 alleviates liver injury by activating TGR5, thereby increasing bile flow and reducing bile acid synthesis. TGR5 signalling mediated by INT-777 induces the release of GLP-1 (glucagon-like peptide-1), improving liver and pancreatic function in obese mice. | ||
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