About 14 results found for searched term "β-catenin-IN-2" (0.117 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M14939 | β-catenin-IN-2 | Wnt/beta-catenin |
| β-catenin-IN-2 is a potent β-catenin inhibitor, compound H1B1, extracted from patent US20150374662A1. β-catenin-IN-2 can be used for the study of colorectal cancer. | ||
| M4829 | WIKI4 | Wnt/beta-catenin |
| WIKI4 is a potent inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM) that inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM). | ||
| M5267 | E7449 | PARP |
| Stenoparib; 2X-121; MGI25036 | ||
| E7449 is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 that also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively. | ||
| M6855 | JW 74 | Wnt/beta-catenin |
| JW 74 is a wnt pathway inhibitor, with an IC50 of 420 nM. JW 74 targets the β-catenin destruction complex (GSK-3 beta /AXIN/APC). JW 74 increases AXIN2 and decreases active β-catenin levels in colorectal cancer (CRC) cells. | ||
| M14933 | KY1220 | Wnt/beta-catenin |
| KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells. | ||
| M21154 | NRX-252114 | Others |
| NRX-25211 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, enhancing the binding of pSer33/S37A β-catenin to β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-25211 was able to promote the degradation of mutant β catenin degradation. | ||
| M21589 | OM-153 | PARP |
| OM-153 is a potent, orally active tankyrase inhibitor with IC50 of 13 nM for tankyrase 1 and 2 nM for tankyrase 2 (TNKS1/2). OM-153 inhibited luciferase based Wnt/β-catenin signal transduction reporter activity with IC50 of 0.63 nM. OM-153 inhibits Wnt/β-catenin signal transduction and proliferation in COLO 320DM. | ||
| M29240 | DK419 | Wnt/beta-catenin |
| DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK. | ||
| M29815 | NRX-103094 | PROTAC |
| NRX-103094 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103094 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM. | ||
| M30259 | (E)-Ferulic acid | Wnt/beta-catenin |
| (E)-Coniferic acid | ||
| (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. | ||
| M31238 | M435-1279 | E1/E2/E3 Enzyme |
| M435-1279 is a UBE2T inhibitor. M435-1279 inhibits the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1. | ||
| M39854 | 2-Hydroxycinnamaldehyde | Wnt/beta-catenin |
| 2-Hydroxycinnamaldehyde is a phenylpropanoid that can be isolated from the bark of Cinnamomum cassia. 2-Hydroxycinnamaldehyde inhibits Wnt/β-catenin, STAT3 signaling. 2-Hydroxycinnamaldehyde induces cell apoptosis 2-Hydroxycinnamaldehyde has antitumor and anti-inflammation activities. | ||
| M58585 | Wnt/β-catenin agonist 1 | Wnt/beta-catenin |
| Wnt/β-catenin agonist 1 is a Wnt/β-catenin signalling pathway agonist, with an EC50 of 0.27 μM. | ||
| M58586 | UU-T02 | Wnt/beta-catenin |
| UUT02; UUT-02 | ||
| UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction, with a Ki of 1.36 μM. UU-T02 inhibits canonical Wnt signaling. | ||
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
