About 33 results found for searched term "β-Lactamase" (0.094 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M39639 | β-Lactamase | Others |
| β-Lactamase is the enzyme produced by bacteria. β-Lactamase mediates β-lactam resistance. | ||
| M41046 | Metallo-β-lactamase-IN-11 | Antibiotic |
| Metallo-β-lactamase-IN-11 is a Metallo-β-lactamases (MBLs) inhibitor, potent against bacterial metallophyllactamase CphA (IC50=45 µM). | ||
| M55788 | β-Lactamase-IN-2 | Others |
| β-Lactamase-IN-2 is a beta-lactamase inhibitor. | ||
| M2635 | Dicloxacillin Sodium | Antibiotic |
| Dicloxacillin is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive/negative aerobic and anaerobic bacteria. | ||
| M2873 | Nafcillin sodium monohydrate | Antibiotic |
| Nafcillin sodium monohydrate is an antibiotic, it reversibly inhibits β-lactamase with Kd of 33 mM. | ||
| M3325 | Captopril | Animal Modeling |
| SQ 14225 | ||
| Captopril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM. It can be used to construct animal models of heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM. | ||
| M3602 | Sulbactam sodium | Antibiotic |
| Sulbactam sodium (Unasyn) is an irreversible β-lactamase inhibitor. | ||
| M3992 | Avibactam | Antibiotic |
| NXL-104 | ||
| Avibactam is a non-β-lactam β-lactamase inhibitor with a spectrum of activity that includes β-lactamase enzymes of classes A, C, and selected D examples. | ||
| M5779 | Methicillin sodium salt | Antibiotic |
| Meticillin sodium | ||
| Meticillin sodium salt is a narrow-spectrum β-lactam antibiotic of the penicillin class, used to treat infections caused by susceptible Gram-positive bacteria, active against beta-lactamase-producing organisms such as Staphylococcus aureus. | ||
| M6174 | Avibactam sodium | Others |
| NXL-104 | ||
| Avibactam sodium is a covalent, reversible β-lactamase inhibitor, inhibits β-lactamase TEM-1 and CTX-M-15 with IC50 of 8 nM and 5 nM, respectively. | ||
| M13463 | Dicloxacillin Sodium hydrate | Antibiotic |
| Dicloxacillin sodium salt monohydrate | ||
| Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) is a narrow-spectrum β-Lactam antibiotic of the penicillin class, is used to treat infections caused by susceptible Gram-positive bacteria, active against beta-lactamase-producing organisms such as Staphylococcus aureus. | ||
| M19905 | Cephalothin | Antibiotic |
| Cephalotin acid; Cephalotin | ||
| Cephalothin (Cephalotin acid) is a beta-lactam antibiotic, inhibits class C β-lactamase AmpC, with an Ki of 0.32 µM. | ||
| M19911 | Sultamicillin Tosylate | Anti-infection |
| Sultamicillin Tosylate is a semi-synthetic β-lactamase inhibitor with an IC50 of 0.8 μM. | ||
| M20481 | Sultamicillin | Antibiotic |
| Sultamicillin is a newly developed antibiotic in which ampicillin and the β-lactamase inhibitor sulbactam are linked as an ester. | ||
| M20709 | Relebactam | Others |
| MK-7655 | ||
| Relebactam (MK-7655) is a potent inhibitor against KPC-2, class A and class C (AmpC) β-lactamases. | ||
| M21623 | Clavulanate Potassium | Antibiotic |
| Potassium Clavulanate-Microcrystalline cellulose(1:1) | ||
| Clavulanate potassium is a potent β-lactamase inhibitor and acts as an antibiotic. | ||
| M22238 | Emetine dihydrochloride hydrate | Autophagy |
| Emetine dihydrochloride hydrate is an alkaloid that has been found in ipecac root and has diverse biological activities. Emetine inhibits NF-κB signaling induced by TNF-α or IL-1β (IC50s = 2 and 4.2 μM, respectively, in a cell-based β-lactamase reporter assay), increases caspase-3/7 activity in ME180 cells (EC50 = 1.1 μM), and is cytotoxic to HeLa cells. | ||
| M25574 | Durlobactam sodium | Antibiotic |
| ETX2514 sodium | ||
| Durlobactam (ETX2514) sodium is an inhibitor of β-lactamase with IC50 values of 4 nM, 14 nM, and 190 nM for Class A KPC-2, Class C AmpC, and Class D OXA-24, respectively. | ||
| M27595 | Enmetazobactam | Antibiotic |
| AAI101 | ||
| Enmetazobactam (AAI101) is an extended-spectrum β-lactamase inhibitor, against many resistant Gram-negative pathogens. | ||
| M27654 | BRL-42715 | Antibiotic |
| BRL-42715 is a potent inhibitor of a broad range of bacterial beta-lactamases (β-lactamase) . | ||
| M27693 | Cefditoren sodium | Antibiotic |
| ME 1206 | ||
| Cefditoren sodium (ME 1206) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren sodium has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren sodium can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections. | ||
| M28246 | Vaborbactam | Antibiotic |
| RPX7009 | ||
| Vaborbactam (RPX7009) is a cyclic boronic acid pharmacophore β-lactamase inhibitor. | ||
| M28436 | Zidebactam | Antibiotic |
| WCK-5107 | ||
| Zidebactam (WCK-5107) is a potent β-lactamase inhibitor. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC50 of 0.26 μg/mL. | ||
| M28681 | Taniborbactam | Antibiotic |
| VNRX-5133 | ||
| Taniborbactam (VNRX-5133) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam is against Gram-negative bacteria. | ||
| M28823 | Zidebactam sodium salt | Antibiotic |
| WCK-5107 sodium salt | ||
| Zidebactam sodium salt (WCK-5107 sodium salt) is a potent β-lactamase inhibitor. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC50 of 0.26 μg/mL. | ||
| M28890 | WCK-4234 | Antibiotic |
| WCK-4234 is a potent β-lactamase inhibitor. WCK-4234 inhibits class A, C, and D β-lactamases activity. WCK-4234 lacks direct antibacterial activity. WCK-4234 potentiates imipenem and meropenem against Enterobacteriaceae with OXA-48/OXA-181 or KPC enzymes, or with combinations of impermeability and AmpC or ESBL activity. WCK-4234 distinctively overcomes resistance mediated by OXA-type carbapenemases. | ||
| M29414 | Taniborbactam hydrochloride | Antibiotic |
| VNRX-5133 hydrochloride | ||
| Taniborbactam hydrochloride (VNRX-5133 hydrochloride) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam hydrochloride has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam hydrochloride is against Gram-negative bacteria. | ||
| M29425 | Avibactam tomilopil | Antibiotic |
| ARX-1796; AV-006 | ||
| Avibactam tomilopil (ARX-1796, AV-006), an Avibactam proagent, is an orally bioavailable β-lactamase inhibitor. Avibactam has a spectrum of inhibition of class A and C β-lactamases, including ESBLs, AmpC and Klebsiella pneumoniae carbapenemase (KPC) enzymes. | ||
| M29605 | ANT3310 sodium | Antibiotic |
| ANT3310 sodium is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC50 values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). ANT3310 sodium potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). ANT3310 sodium can be used in the research of bacterial infection. | ||
| M29850 | IMB-XH1 | Bcl-2 |
| IMB-XH1 is an inhibitor of myeloid cell factor 1 (Mcl-1). IMB-XH1 is a non-competitive Delhi metallo-β-lactamase (NDM-1) inhibitor. The IC50s of IMB-XH1 against metallo-β-lactamases NDM-1, IMP-4, ImiS and L1 are 0.4637 μM, 3.980 μM, 0.2287 μM and 1.158 μM, respectively. | ||
| M30072 | Nitrocefin | Antibiotic |
| Nitrocefin is a chromogenic β-lactamase substrate that undergoes distinctive color change from yellow to red as the amide bond in the β-lactam ring is hydrolyzed by β-lactamase. Nitrocefin is used in competitive inhibition studies in developmental work on β-lactamase-resistant antibiotics. | ||
| M30319 | Clavulanic acid | Antibiotic |
| Clavulanic acid is a naturally occurring powerful bacterial β-lactamases inhibitor for research of infections caused by bacteria, including infections of the ears. Clavulanic acid is active against a wide spectrum of gram-positive and gram-negative bacterias. | ||
| M30364 | Clavulanate lithium | Antibiotic |
| Clavulanate lithium is a potent β-lactamase inhibitor and acts as an antibiotic. | ||
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