About 1 result found for searched term "(R)-NX-2127" (0.144 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M55647 | (R)-NX-2127 | BTK |
| compound 28 | ||
| (R)-NX-2127 (compound 28) is a first-in-class, orally bioavailable Bruton’s Tyrosine Kinase (Btk) degrader. (R)-NX-2127 mediates the degradation of transcription factors IKZF1 and IKZF3 through molecular glue interactions with the cereblon E3 ubiquitin ligase complex. NX-2127 degrades common BTK resistance mutants, including BTKC481S. | ||
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