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Zuclomiphene citrate

Cat. No. M10910
Zuclomiphene citrate  Structure
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Biological Activity

Zuclomiphene citrate is a cis isomer of clomiphene citrate. Zuclomiphene citrate has an anti-estrogen effect and inhibits the secretion of luteinizing hormone (LH) more than trans isomers. Zuclomiphene citrate is also an oral active cholesterol lowering agent.

Chemical Information
Molecular Weight 598.09
Formula C32H36ClNO8
CAS Number 7619-53-6
Solubility (25°C) N/A
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Joshua A Earl, et al. Expert Rev Endocrinol Metab. Enclomiphene citrate: A treatment that maintains fertility in men with secondary hypogonadism

[2] Sevann Helo, et al. BJU Int. Serum levels of enclomiphene and zuclomiphene in men with hypogonadism on long-term clomiphene citrate treatment

[3] Gregory K Fontenot, et al. BJU Int. Differential effects of isomers of clomiphene citrate on reproductive tissues in male mice

[4] S L Young, et al. Fertil Steril. Serum concentrations of enclomiphene and zuclomiphene across consecutive cycles of clomiphene citrate therapy in anovulatory infertile women

[5] G E Schmidt, et al. Am J Obstet Gynecol. The effects of enclomiphene and zuclomiphene citrates on mouse embryos fertilized in vitro and in vivo

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