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ZN-c3

Cat. No. M11346
ZN-c3  Structure
Size Price Availability Quantity
5mg USD 390  USD390 In stock
10mg USD 620  USD620 In stock
25mg USD 1125  USD1125 In stock
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Quality Control & Documentation
Biological Activity

Zn-c3 is an orally active, highly potent and selective Wee1 inhibitor (IC50=3.9 nM). Zn-c3 could be used in cancer research.

Chemical Information
Molecular Weight 526.63
Formula C29H34N8O2
CAS Number 2376146-48-2
Solubility (25°C) DMSO ≥ 200 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xiangbing Meng, et al. Front Med (Lausanne). Recent Advances of WEE1 Inhibitors and Statins in Cancers With p53 Mutations

[2] Peter Q Huang, et al. J Med Chem. Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer

[3] Xiao-Nan Wu, et al. Phys Chem Chem Phys. Highly regioselective hydride transfer, oxidative dehydrogenation, and hydrogen-atom abstraction in the thermal gas-phase chemistry of [Zn(OH)](+)/C3H8

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Keywords: ZN-c3 supplier, Wee1, inhibitors, activators


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