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ZN-c3

Cat. No. M11346
ZN-c3  Structure
Size Price Availability Quantity
5mg USD 390  USD390 In stock
10mg USD 620  USD620 In stock
25mg USD 1125  USD1125 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Zn-c3 is an orally active, highly potent and selective Wee1 inhibitor (IC50=3.9 nM). Zn-c3 could be used in cancer research.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 526.63
Formula C29H34N8O2
CAS Number 2376146-48-2
Purity >99%
Solubility DMSO ≥ 200 mg/mL
Storage at -20°C
References

[1] Xiangbing Meng, et al. Front Med (Lausanne). Recent Advances of WEE1 Inhibitors and Statins in Cancers With p53 Mutations

[2] Peter Q Huang, et al. J Med Chem. Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer

[3] Xiao-Nan Wu, et al. Phys Chem Chem Phys. Highly regioselective hydride transfer, oxidative dehydrogenation, and hydrogen-atom abstraction in the thermal gas-phase chemistry of [Zn(OH)](+)/C3H8

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Keywords: ZN-c3 supplier, Wee1, inhibitors

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